5EKV

Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.

Summary for 5EKV

• Entry DOI: 10.2210/pdb5ekv/pdb
• Descriptor: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione (3 entities in total)
• Functional Keywords: complex, inhibitor, translation, eif4e
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm, P-body : P06730
• Total number of polymer chains: 4
• Total formula weight: 54769.63

Authors

Nowicki, M.W.,Walkinshaw, M.D.,Fischer, P.M. (deposition date: 2015-11-04, release date: 2016-09-07, Last modification date: 2024-01-10)

• Primary citation: Soukarieh, F.,Nowicki, M.W.,Bastide, A.,Poyry, T.,Jones, C.,Dudek, K.,Patwardhan, G.,Meullenet, F.,Oldham, N.J.,Walkinshaw, M.D.,Willis, A.E.,Fischer, P.M.; Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.; Eur.J.Med.Chem., 124:200-217, 2016; PubMed: 27592390; DOI: 10.1016/j.ejmech.2016.08.047

Experimental method

X-RAY DIFFRACTION (3.61 Å)