5EKV

Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Eukaryotic translation initiation factor 4E	polymer	217	25130.2	2	UniProt (P06730) Pfam (PF01652)	Homo sapiens (Human)	eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein
2	B, D (B, D)	Eukaryotic translation initiation factor 4E-binding protein 1	polymer	14	1861.2	2	UniProt (Q13541)	Homo sapiens	eIF4E-binding protein 1,Phosphorylated heat- and acid-stable protein regulated by insulin 1,PHAS-I
3	E, F (A, C)	3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione	non-polymer		393.3	2	Chemie (5PQ)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	53983.0
Non-Polymers*	Number of molecules	2
	Total formula weight	786.7
All*	Total formula weight	54769.6

*Water molecules are not included.