4EFU

Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid benzyl-methyl-amide

Summary for 4EFU

Entry DOI	10.2210/pdb4efu/pdb
Related	3B28 4EEH 4EFT
Descriptor	Heat shock protein HSP 90-alpha, N-benzyl-6-hydroxy-N-methyl-3-(3-methylbenzyl)-1H-indazole-5-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	atp binding, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	26195.34
Authors	Musil, D.,Lehmann, M.,Graedler, U.,Buchstaller, H.-P. (deposition date: 2012-03-30, release date: 2012-06-27, Last modification date: 2024-03-20)
Primary citation	Buchstaller, H.-P.,Eggenweiler, H.-M.,Sirrenberg, C.,Graedler, U.,Musil, D.,Hoppe, E.,Zimmermann, A.,Schwartz, H.,Maerz, J.,Bomke, J.,Wegener, A.,Wolf, M. Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90 Bioorg.Med.Chem.Lett., 22:4396-4403, 2012 Cited by PubMed: 22632933 DOI: 10.1016/j.bmcl.2012.04.121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation