4EFT

Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-Cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)-propionitrile

Summary for 4EFT

• Entry DOI: 10.2210/pdb4eft/pdb
• Related: 3B28 4EEH 4EFU
• Descriptor: Heat shock protein HSP 90-alpha, (2R)-3-cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)propanenitrile (3 entities in total)
• Functional Keywords: atp binding, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 1
• Total formula weight: 25983.16

Authors

Musil, D.,Lehmann, M.,Graedler, U.,Buchstaller, H.-P. (deposition date: 2012-03-30, release date: 2012-06-27, Last modification date: 2024-03-20)

• Primary citation: Buchstaller, H.-P.,Eggenweiler, H.-M.,Sirrenberg, C.,Graedler, U.,Musil, D.,Hoppe, E.,Zimmermann, A.,Schwartz, H.,Maerz, J.,Bomke, J.,Wegener, A.,Wolf, M.; Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90; Bioorg.Med.Chem.Lett., 22:4396-4403, 2012; PubMed: 22632933; DOI: 10.1016/j.bmcl.2012.04.121

Experimental method

X-RAY DIFFRACTION (2.12 Å)