4EFT
Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-Cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)-propionitrile
Summary for 4EFT
Entry DOI | 10.2210/pdb4eft/pdb |
Related | 3B28 4EEH 4EFU |
Descriptor | Heat shock protein HSP 90-alpha, (2R)-3-cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)propanenitrile (3 entities in total) |
Functional Keywords | atp binding, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 25983.16 |
Authors | Musil, D.,Lehmann, M.,Graedler, U.,Buchstaller, H.-P. (deposition date: 2012-03-30, release date: 2012-06-27, Last modification date: 2024-03-20) |
Primary citation | Buchstaller, H.-P.,Eggenweiler, H.-M.,Sirrenberg, C.,Graedler, U.,Musil, D.,Hoppe, E.,Zimmermann, A.,Schwartz, H.,Maerz, J.,Bomke, J.,Wegener, A.,Wolf, M. Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90 Bioorg.Med.Chem.Lett., 22:4396-4403, 2012 Cited by PubMed: 22632933DOI: 10.1016/j.bmcl.2012.04.121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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