3O88
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3o88 by Molmil](/molmil-images/mine/3o88) | Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor | 分子名称: | 3-[(2R)-2-[(benzylsulfonyl)amino]-2-(dihydroxyboranyl)ethyl]benzoic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Eidam, O, Romagnoli, C, Karpiak, J, Shoichet, B.K. | 登録日 | 2010-08-02 | 公開日 | 2010-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors J.Med.Chem., 53, 2010
|
|
3O87
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3o87 by Molmil](/molmil-images/mine/3o87) | Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor | 分子名称: | 4-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Eidam, O, Romagnoli, C, Karpiak, J, Shoichet, B.K. | 登録日 | 2010-08-02 | 公開日 | 2010-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors J.Med.Chem., 53, 2010
|
|
3O86
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3o86 by Molmil](/molmil-images/mine/3o86) | Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor | 分子名称: | Beta-lactamase, PHOSPHATE ION, {[(benzylsulfonyl)amino]methyl}boronic acid | 著者 | Eidam, O, Romagnoli, C, Karpiak, J, Shoichet, B.K. | 登録日 | 2010-08-02 | 公開日 | 2010-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors J.Med.Chem., 53, 2010
|
|
3NY4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ny4 by Molmil](/molmil-images/mine/3ny4) | Crystal Structure of BlaC-K73A bound with Cefamandole | 分子名称: | (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Tremblay, L.W, Blanchard, J.S. | 登録日 | 2010-07-14 | 公開日 | 2010-11-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | 主引用文献 | Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants. Biochemistry, 49, 2010
|
|
3NIA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3nia by Molmil](/molmil-images/mine/3nia) | GES-2 carbapenemase tazobactam complex | 分子名称: | (3S)-3-(dihydroxy-lambda~4~-sulfanyl)-4-(1H-1,2,3-triazol-1-yl)-D-valine, Beta-lactamase GES-2, TAZOBACTAM INTERMEDIATE | 著者 | Frase, H, Smith, C.A, Toth, M, Vakulenko, S.B. | 登録日 | 2010-06-15 | 公開日 | 2011-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Inhibition of the GES-2 beta-Lactamse by Tazobactam: Detection of Reaction
Intermediates by UV and Mass Spectrometry and X-Ray Crystallography To be Published
|
|
3NI9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ni9 by Molmil](/molmil-images/mine/3ni9) | GES-2 carbapenemase apo form | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase GES-2 | 著者 | Frase, H, Smith, C.A, Toth, M, Vakulenko, S.B. | 登録日 | 2010-06-15 | 公開日 | 2011-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Kinetic and structural requirements for carbapenemase activity in GES-type beta-lactamases. Biochemistry, 54, 2015
|
|
3NDG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ndg by Molmil](/molmil-images/mine/3ndg) | |
3NDE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3nde by Molmil](/molmil-images/mine/3nde) | |
3NCK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3nck by Molmil](/molmil-images/mine/3nck) | |
3NC8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3nc8 by Molmil](/molmil-images/mine/3nc8) | |
3NBL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3nbl by Molmil](/molmil-images/mine/3nbl) | |
3N8S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n8s by Molmil](/molmil-images/mine/3n8s) | Crystal Structure of BlaC-E166A covalently bound with Cefamandole | 分子名称: | (2R)-2-[(1R)-1-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-2-oxoethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Tremblay, L.W, Blanchard, J.S. | 登録日 | 2010-05-28 | 公開日 | 2010-11-24 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants. Biochemistry, 49, 2010
|
|
3N8R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n8r by Molmil](/molmil-images/mine/3n8r) | |
3N8L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n8l by Molmil](/molmil-images/mine/3n8l) | |
3N7W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n7w by Molmil](/molmil-images/mine/3n7w) | |
3N6I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n6i by Molmil](/molmil-images/mine/3n6i) | |
3N4I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n4i by Molmil](/molmil-images/mine/3n4i) | Crystal structure of the SHV-1 D104E beta-lactamase/beta-lactamase inhibitor protein (BLIP) complex | 分子名称: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein | 著者 | Hanes, M.S, Reynolds, K.A, McNamara, C, Ghosh, P, Bonomo, R.A, Kirsch, J.F, Handel, T.M. | 登録日 | 2010-05-21 | 公開日 | 2011-03-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Specificity and Cooperativity at beta-lactamase Position 104 in TEM-1/BLIP and SHV-1/BLIP interactions Proteins, 79, 2011
|
|
3MXS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mxs by Molmil](/molmil-images/mine/3mxs) | SHV-1 beta-lactamase complex with compound 2 | 分子名称: | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, N-[(dihydroxyboranyl)methyl]-Nalpha-[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]-D-tyrosinamide | 著者 | Ke, W, van den Akker, F. | 登録日 | 2010-05-07 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors. Antimicrob.Agents Chemother., 55, 2011
|
|
3MXR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mxr by Molmil](/molmil-images/mine/3mxr) | SHV-1 beta-lactamase complex with compound 1 | 分子名称: | ({[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-4-(4-hydroxyphenyl)butanoyl]amino}methyl)boronic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Ke, W, van den Akker, F. | 登録日 | 2010-05-07 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors. Antimicrob.Agents Chemother., 55, 2011
|
|
3MKF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mkf by Molmil](/molmil-images/mine/3mkf) | SHV-1 beta-lactamase complex with GB0301 | 分子名称: | ({[(2R)-2-{[(4-ethyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}methyl)boronic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | van den Akker, F, Ke, W. | 登録日 | 2010-04-14 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors. Antimicrob.Agents Chemother., 55, 2011
|
|
3MKE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mke by Molmil](/molmil-images/mine/3mke) | SHV-1 beta-lactamase complex with LP06 | 分子名称: | 2-[(~{Z})-[1-(2-azanyl-1,3-thiazol-4-yl)-2-oxidanylidene-2-[[(6~{S})-4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl]methylamino]ethylidene]amino]oxy-2-methyl-propanoic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... | 著者 | van den Akker, F, Ke, W. | 登録日 | 2010-04-14 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors. Antimicrob.Agents Chemother., 55, 2011
|
|
3M6H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3m6h by Molmil](/molmil-images/mine/3m6h) | Crystal Structure of Post-isomerized Ertapenem Covalent Adduct with TB B-lactamase | 分子名称: | (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Tremblay, L.W. | 登録日 | 2010-03-15 | 公開日 | 2010-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.994 Å) | 主引用文献 | Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry, 49, 2010
|
|
3M6B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3m6b by Molmil](/molmil-images/mine/3m6b) | Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase | 分子名称: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Tremblay, L.W, Fan, F, Blanchard, J.S. | 登録日 | 2010-03-15 | 公開日 | 2010-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry, 49, 2010
|
|
3M2K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3m2k by Molmil](/molmil-images/mine/3m2k) | Crystal Structure of fluorescein-labeled Class A -beta lactamase PenP in complex with cefotaxime | 分子名称: | Beta-lactamase, CEFOTAXIME, C3' cleaved, ... | 著者 | Zhao, Y.X, Leung, Y.C, Wong, W.T. | 登録日 | 2010-03-07 | 公開日 | 2011-03-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural studies of the mechanism for biosensing antibiotics in a fluorescein-labeled beta-lactamase. BMC Struct. Biol., 11, 2011
|
|
3M2J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3m2j by Molmil](/molmil-images/mine/3m2j) | |