3O87

Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor

Summary for 3O87

Entry DOI	10.2210/pdb3o87/pdb
Related	3O86 3O88
Descriptor	Beta-lactamase, 4-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	contains alpha helices and a beta sandwich / beta-lactamase-like fold / ampc beta-lactamase, class c, hydrolase, cephalosporinase
Biological source	Escherichia coli
Cellular location	Periplasm: P00811
Total number of polymer chains	2
Total formula weight	79816.96
Authors	Eidam, O.,Romagnoli, C.,Karpiak, J.,Shoichet, B.K. (deposition date: 2010-08-02, release date: 2010-11-03, Last modification date: 2023-09-06)
Primary citation	Eidam, O.,Romagnoli, C.,Caselli, E.,Babaoglu, K.,Pohlhaus, D.T.,Karpiak, J.,Bonnet, R.,Shoichet, B.K.,Prati, F. Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors J.Med.Chem., 53:7852-7863, 2010 Cited by PubMed: 20945905 DOI: 10.1021/jm101015z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation