3NIA

GES-2 carbapenemase tazobactam complex

Summary for 3NIA

• Entry DOI: 10.2210/pdb3nia/pdb
• Related: 3NI9
• Descriptor: Beta-lactamase GES-2, TAZOBACTAM INTERMEDIATE, (3S)-3-(dihydroxy-lambda~4~-sulfanyl)-4-(1H-1,2,3-triazol-1-yl)-D-valine, ... (4 entities in total)
• Functional Keywords: beta-lactamase, antibiotic resistance, carbapenemase, lactamase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 29861.74

Authors

Frase, H.,Smith, C.A.,Toth, M.,Vakulenko, S.B. (deposition date: 2010-06-15, release date: 2011-03-02, Last modification date: 2023-09-06)

• Primary citation: Frase, H.,Smith, C.A.,Toth, M.,Champion, M.M.,Mobashery, S.,Vakulenko, S.B.; Inhibition of the GES-2 beta-Lactamse by Tazobactam: Detection of Reaction Intermediates by UV and Mass Spectrometry and X-Ray Crystallography; To be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)