3O86

Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor

Summary for 3O86

• Entry DOI: 10.2210/pdb3o86/pdb
• Related: 3O87 3O88
• Descriptor: Beta-lactamase, {[(benzylsulfonyl)amino]methyl}boronic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: contains alpha helices and a beta sandwich / beta-lactamase-like fold / ampc beta-lactamase, class c, hydrolase, cephalosporinase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79823.91

Authors

Eidam, O.,Romagnoli, C.,Karpiak, J.,Shoichet, B.K. (deposition date: 2010-08-02, release date: 2010-11-03, Last modification date: 2023-09-06)

• Primary citation: Eidam, O.,Romagnoli, C.,Caselli, E.,Babaoglu, K.,Pohlhaus, D.T.,Karpiak, J.,Bonnet, R.,Shoichet, B.K.,Prati, F.; Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors; J.Med.Chem., 53:7852-7863, 2010; PubMed: 20945905; DOI: 10.1021/jm101015z

Experimental method

X-RAY DIFFRACTION (1.6 Å)