PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

---

2VQM	Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor 分子名称: HISTONE DEACETYLASE 4, N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide, POTASSIUM ION, ... 著者 Bottomley, M.J, Lo Surdo, P, Di Giovine, P, Cirillo, A, Scarpelli, R, Ferrigno, F, Jones, P, Neddermann, P, De Francesco, R, Steinkuhler, C, Gallinari, P, Carfi, A. 登録日 2008-03-17 公開日 2008-07-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain. J.Biol.Chem., 283, 2008
3DY4	Crystal structure of yeast 20S proteasome in complex with spirolactacystin 分子名称: Omuralide, open form, Proteasome component C1, ... 著者 Groll, M, Balskus, E, Jacobsen, E. 登録日 2008-07-25 公開日 2008-11-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural analysis of spiro beta-lactone proteasome inhibitors. J.Am.Chem.Soc., 130, 2008
3HQU	PHD2:Fe:UN9:partial HIF1-alpha substrate complex 分子名称: Egl nine homolog 1, FE (II) ION, Hypoxia-inducible factor 1 alpha, ... 著者 Chowdhury, R, McDonough, M.A, Schofield, C.J. 登録日 2009-06-08 公開日 2009-07-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17, 2009
2W9F	Crystal Structure of CDK4 in complex with a D-type cyclin 分子名称: CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1 著者 Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. 登録日 2009-01-23 公開日 2009-03-10 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Proc.Natl.Acad.Sci.USA, 106, 2009
3DZ4	Human AdoMetDC with 5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine 分子名称: 1,4-DIAMINOBUTANE, 3-[{[(2R,3S,4R,5R)-5-(6-amino-8-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)amino]propanamid e, S-adenosylmethionine decarboxylase alpha chain, ... 著者 Bale, S, McCloskey, D.E, Pegg, A.E, Secrist III, J.A, Guida, W.C, Ealick, S.E. 登録日 2008-07-29 公開日 2009-03-10 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine J.Med.Chem., 52, 2009
3HTU	Crystal structure of the human VPS25-VPS20 subcomplex 分子名称: Vacuolar protein-sorting-associated protein 20, Vacuolar protein-sorting-associated protein 25 著者 Im, Y.J, Hurley, J.H. 登録日 2009-06-12 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Dev.Cell, 17, 2009
2WMS	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 分子名称: SERINE/THREONINE-PROTEIN KINASE CHK1, [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone 著者 Matthews, T.P, Klair, S, Burns, S, Boxall, K, Cherry, M, Fisher, M, Westwood, I.M, Walton, M.I, McHardy, T, Cheung, K.-M.J, Van Montfort, R, Williams, D, Aherne, G.W, Garrett, M.D, Reader, J, Collins, I. 登録日 2009-07-03 公開日 2009-07-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening. J.Med.Chem., 52, 2009
3E0N	The X-ray structure of Human Prostasin in complex with DFFR-chloromethyl ketone inhibitor 分子名称: DPN-PHE-ARM, GLYCEROL, Prostasin heavy chain, ... 著者 Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. 登録日 2008-07-31 公開日 2009-06-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18, 2009
3HX0	ternary complex of L277A, H511A, R514 mutant pol lambda bound to a 2 nucleotide gapped DNA substrate with a scrunched dA 分子名称: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*T)-3', 5'-D(*CP*GP*GP*CP*AP*AP*AP*TP*AP*CP*TP*G)-3', ... 著者 Garcia-Diaz, M, Bebenek, K, Larrea, A.A, Havener, J.M, Perera, L, Krahn, J.M, Pedersen, L.C, Ramsden, D.A, Kunkel, T.A. 登録日 2009-06-19 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Scrunching During DNA Repair Synthesis To be Published
2WMO	Structure of the complex between DOCK9 and Cdc42. 分子名称: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Yang, J, Roe, S.M, Barford, D. 登録日 2009-07-02 公開日 2009-09-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor. Science, 325, 2009
2WNS	Human Orotate phosphoribosyltransferase (OPRTase) domain of Uridine 5' -monophosphate synthase (UMPS) in complex with its substrate orotidine 5'-monophosphate (OMP) 分子名称: CHLORIDE ION, OROTATE PHOSPHORIBOSYLTRANSFERASE, OROTIDINE-5'-MONOPHOSPHATE 著者 Moche, M, Roos, A, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotyenova, T, Kotzch, A, Nielsen, T.K, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, VanDenBerg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P. 登録日 2009-07-19 公開日 2009-08-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with its Substrate Orotidine 5'-Monophosphate (Omp) To be Published
3DZ7	Human AdoMetDC with 5'-[(carboxamidomethyl)methylamino]-5'-deoxy-8-methyladenosine 分子名称: 1,4-DIAMINOBUTANE, 2-[{[(2R,3S,4R,5R)-5-(6-amino-8-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)amino]acetamide, S-adenosylmethionine decarboxylase alpha chain, ... 著者 Bale, S, McCloskey, D.E, Pegg, A.E, Secrist III, J.A, Guida, W.C, Ealick, S.E. 登録日 2008-07-29 公開日 2009-03-10 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine J.Med.Chem., 52, 2009
3E16	X-ray structure of human prostasin in complex with Benzoxazole warhead peptidomimic, lysine in P3 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Prostasin, ... 著者 Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. 登録日 2008-08-01 公開日 2008-09-09 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg.Med.Chem.Lett., 18, 2008
2WMQ	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 分子名称: N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE, SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Matthews, T.P, Klair, S, Burns, S, Boxall, K, Cherry, M, Fisher, M, Westwood, I.M, Walton, M.I, McHardy, T, Cheung, K.-M.J, Van Montfort, R, Williams, D, Aherne, G.W, Garrett, M.D, Reader, J, Collins, I. 登録日 2009-07-03 公開日 2009-07-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening. J.Med.Chem., 52, 2009
2WMX	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 分子名称: 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine, SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Matthews, T.P, Klair, S, Burns, S, Boxall, K, Cherry, M, Fisher, M, Westwood, I.M, Walton, M.I, McHardy, T, Cheung, K.-M.J, Van Montfort, R, Williams, D, Aherne, G.W, Garrett, M.D, Reader, J, Collins, I. 登録日 2009-07-03 公開日 2009-07-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening. J.Med.Chem., 52, 2009
2WMU	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 分子名称: 6-MORPHOLIN-4-YL-9H-PURINE, SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Matthews, T.P, Klair, S, Burns, S, Boxall, K, Cherry, M, Fisher, M, Westwood, I.M, Walton, M.I, McHardy, T, Cheung, K.-M.J, Van Montfort, R, Williams, D, Aherne, G.W, Garrett, M.D, Reader, J, Collins, I. 登録日 2009-07-03 公開日 2009-07-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening. J.Med.Chem., 52, 2009
3HOD	Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid 分子名称: (2S)-2-(4-benzylphenoxy)-3-phenylpropanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Pochetti, G, Montanari, R, Mazza, F, Loiodice, F, Fracchiolla, G, Laghezza, A, Lavecchia, A, Novellino, E. 登録日 2009-06-02 公開日 2009-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on Skeletal Muscle Function J.Med.Chem., 52, 2009
2WOS	Structure of human S100A7 in complex with 2,6 ANS 分子名称: 6-[(1E)-CYCLOHEXA-2,4-DIEN-1-YLIDENEAMINO]NAPHTHALENE-2-SULFONATE, CALCIUM ION, PROTEIN S100-A7, ... 著者 Leon, R, Murray, J.I, Cragg, G, Farnell, B, Pace, T.C, Bohne, C, Boulanger, M.J, Hof, F. 登録日 2009-07-27 公開日 2009-10-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Identification and Characterization of Binding Sites on S100A7, a Participant in Cancer and Inflammation Pathways. Biochemistry, 48, 2009
3HOP	Structure of the actin-binding domain of human filamin A 分子名称: Filamin-A, PHOSPHATE ION 著者 Clark, A.R, Sawyer, G.M, Robertson, S.P, Sutherland-Smith, A.J. 登録日 2009-06-03 公開日 2009-10-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders Hum.Mol.Genet., 18, 2009
3DV5	Crystal structure of human beta-secretase in complex with NVP-BAV544 分子名称: (3S,14R,16S)-16-[(1R)-1-hydroxy-2-{[3-(1-methylethyl)benzyl]amino}ethyl]-3,4,14-trimethyl-1,4-diazacyclohexadecane-2,5- dione, Beta-secretase 1 著者 Rondeau, J.-M. 登録日 2008-07-18 公開日 2009-02-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg.Med.Chem.Lett., 19, 2009
2WQN	Structure of ADP-bound human Nek7 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICKEL (II) ION, ... 著者 Richards, M.W, Bayliss, R. 登録日 2009-08-24 公開日 2009-12-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9. Mol.Cell, 36, 2009
3HQR	PHD2:Mn:NOG:HIF1-alpha substrate complex 分子名称: Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ... 著者 Chowdhury, R, McDonough, M.A, Schofield, C.J. 登録日 2009-06-08 公開日 2009-07-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17, 2009
3HRW	Crystal structure of hemoglobin from mouse (Mus musculus)at 2.8 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE 著者 Sundaresan, S.S, Ramesh, P, Ponnuswamy, M.N. 登録日 2009-06-10 公開日 2009-06-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of hemoglobin from mouse (Mus musculus) compared with those from other small animals and humans. Acta Crystallogr.,Sect.F, 77, 2021
3HV5	Human p38 MAP Kinase in Complex with RL24 分子名称: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase 14, ... 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2009-06-15 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Displacement assay for the detection of stabilizers of inactive kinase conformations. J.Med.Chem., 53, 2010
3HW8	ternary complex of DNA polymerase lambda of a two nucleotide gapped DNA substrate with a C in the scrunch site 分子名称: 1,2-ETHANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*T)-3', ... 著者 Garcia-Diaz, M, Bebenek, K, Larrea, A.A, Havener, J.M, Perera, L, Krahn, J.M, Pedersen, L.C, Ramsden, D.A, Kunkel, T.A. 登録日 2009-06-17 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Scrunching Durning DNA Repair Synthesis To be Published

<277278279280281282283284285286287288289290291292>