2WNS

Human Orotate phosphoribosyltransferase (OPRTase) domain of Uridine 5' -monophosphate synthase (UMPS) in complex with its substrate orotidine 5'-monophosphate (OMP)

Summary for 2WNS

Related2JGY 2V30
DescriptorOROTATE PHOSPHORIBOSYLTRANSFERASE, OROTIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsalternative splicing, multifunctional enzyme, lyase, transferase, polymorphism, decarboxylase, phosphoprotein, disease mutation, glycosyltransferase, pyrimidine biosynthesis
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight46002.22
Authors
Primary citation
Moche, M.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotyenova, T.,Kotzch, A.,Nielsen, T.K.,Nyman, T.,Persson, C.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Vandenberg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P.
Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with its Substrate Orotidine 5'-Monophosphate (Omp)
To be Published,
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.240500.9%1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution