Crystal structure of yeast 20S proteasome in complex with spirolactacystin

Summary for 3DY4

Related1RYP 3DY3
DescriptorProteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (16 entities in total)
Functional Keywordsproteasome, inhibitor, protein degradation, ubiquitin-proteasome-pathway, hydrolase, nucleus, protease, threonine protease, phosphoprotein, zymogen
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight705067.22
Groll, M.,Balskus, E.,Jacobsen, E. (deposition date: 2008-07-25, release date: 2008-11-04, Last modification date: 2014-08-13)
Primary citation
Groll, M.,Balskus, E.P.,Jacobsen, E.N.
Structural analysis of spiro beta-lactone proteasome inhibitors.
J.Am.Chem.Soc., 130:14981-14983, 2008
PubMed: 18928262 (PDB entries with the same primary citation)
DOI: 10.1021/ja806059t
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers181.0%6.3%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16