3DV5
Crystal structure of human beta-secretase in complex with NVP-BAV544
Summary for 3DV5
Entry DOI | 10.2210/pdb3dv5/pdb |
Related | 3DUY 3DV1 |
Descriptor | Beta-secretase 1, (3S,14R,16S)-16-[(1R)-1-hydroxy-2-{[3-(1-methylethyl)benzyl]amino}ethyl]-3,4,14-trimethyl-1,4-diazacyclohexadecane-2,5- dione (3 entities in total) |
Functional Keywords | beta-secretase, memapsin2, bace1, aspartic protease, alzheimer's disease, enzyme inhibitor complex, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, transmembrane, zymogen |
Biological source | Homo sapiens |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 3 |
Total formula weight | 135795.16 |
Authors | Rondeau, J.-M. (deposition date: 2008-07-18, release date: 2009-02-24, Last modification date: 2023-08-30) |
Primary citation | Machauer, R.,Laumen, K.,Veenstra, S.,Rondeau, J.M.,Tintelnot-Blomley, M.,Betschart, C.,Jaton, A.L.,Desrayaud, S.,Staufenbiel, M.,Rabe, S.,Paganetti, P.,Neumann, U. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg.Med.Chem.Lett., 19:1366-1370, 2009 Cited by PubMed: 19195887DOI: 10.1016/j.bmcl.2009.01.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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