2VQM

Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor

Summary for 2VQM

Related2VQW 2VQQ 2VQO 2VQV 2VQJ
DescriptorHISTONE DEACETYLASE 4, POTASSIUM ION, N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide, ... (5 entities in total)
Functional Keywordsinhibitor, repressor, chromatin, coiled coil, histone deacetylase, transcription regulation, ubl conjugation, chromatin regulator, polymorphism, transcription, phosphoprotein, hdac, zinc, hdaci, nucleus, hydrolase, cytoplasm
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P56524
Total number of polymer chains1
Total molecular weight45054.83
Authors
Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. (deposition date: 2008-03-17, release date: 2008-07-08, Last modification date: 2011-07-13)
Primary citation
Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A.
Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283:26694-, 2008
PubMed: 18614528 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M803514200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2585 0.8% 6.4% 16.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02