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2VQM

Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
HISTONE DEACETYLASE 4polymer41344477.41UniProt (P56524)
Pfam (PF00850)
HOMO SAPIENS (HUMAN)HD4
2B, C
(A)
POTASSIUM IONnon-polymer39.12Chemie (K)
3D
(A)
N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamidenon-polymer368.41Chemie (HA3)
4E, F
(A)
ZINC IONnon-polymer65.42Chemie (ZN)
5G
(A)
waterwater18.0360Chemie (HOH)
Sequence modifications
A: 1 - 3 (PDB: 2VQM)
A: 4 - 413 (UniProt: P56524)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight44477.4
Non-Polymers*Number of molecules5
Total formula weight577.4
All*Total formula weight45054.8
*Water molecules are not included.

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PDB entries from 2025-07-23

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