PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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4AWL	The NF-Y transcription factor is structurally and functionally a sequence specific histone 分子名称: HSP70 PROMOTER FRAGMENT, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA, ... 著者 Nardini, M, Gnesutta, N, Donati, G, Gatta, R, Forni, C, Fossati, A, Vonrhein, C, Moras, D, Romier, C, Mantovani, R, Bolognesi, M. 登録日 2012-06-04 公開日 2013-01-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Sequence-Specific Transcription Factor NF-Y Displays Histone-Like DNA Binding and H2B-Like Ubiquitination. Cell(Cambridge,Mass.), 152, 2013
7KDZ	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to TP-238 分子名称: 1,2-ETHANEDIOL, 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2020-10-09 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development Organic & Biomolecular Chemistry, 18(27), 2020
8H6P	Complex structure of CDK2/Cyclin E1 and a potent, selective macrocyclic inhibitor 分子名称: (7S,10R)-11-oxa-2,4,5,13,17,23-hexaazatetracyclo[17.3.1.1~3,6~.1~7,10~]pentacosa-1(23),3(25),5,19,21-pentaene-12,18-dione, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 著者 Ren, X. 登録日 2022-10-18 公開日 2023-02-22 最終更新日 2023-03-29 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. Acs Med.Chem.Lett., 14, 2023
8HBD	Cryo-EM structure of IRL1620-bound ETBR-Gi complex 分子名称: Endothelin receptor type B,Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Yuan, Q, Ji, Y, Jiang, Y, Duan, J, Xu, H.E. 登録日 2022-10-28 公開日 2023-03-22 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
8HCX	Cryo-EM structure of Endothelin1-bound ETBR-Gq complex 分子名称: Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J. 登録日 2022-11-03 公開日 2023-03-22 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
2FUU	NMR solution structure of the PHD domain from the human BPTF in complex with H3(1-15)K4me3 peptide 分子名称: Histone H3, ZINC ION, bromodomain PHD finger transcription factor 著者 Ilin, S, Patel, D.J. 登録日 2006-01-27 公開日 2006-07-11 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006
8FC8	Cryo-EM structure of the human TRPV4 in complex with GSK1016790A 分子名称: CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 著者 Kwon, D.H, Lee, S.-Y, Zhang, F. 登録日 2022-12-01 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
7KDW	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to Compound 6 (HZ01052) 分子名称: 1,2-ETHANEDIOL, Nucleosome-remodeling factor subunit BPTF, cyclopropyl[7-({2-[(prop-2-yn-1-yl)amino]pyrimidin-4-yl}amino)-3,4-dihydroquinolin-1(2H)-yl]methanone 著者 Chan, A, Schonbrunn, E. 登録日 2020-10-09 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development Organic and Biomolecular Chemistry, 18(27), 2020
5D1C	Crystal structure of D233G-Y306F HDAC8 in complex with a tetrapeptide substrate 分子名称: GLYCEROL, HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, ... 著者 Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2015-08-04 公開日 2015-10-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.422 Å) 主引用文献 Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015
7JVV	Crystal structure of human histone deacetylase 8 (HDAC8) E66D/Y306F double mutation complexed with a tetrapeptide substrate 分子名称: 1,2-ETHANEDIOL, ACE-ARG-HIS-ALY-ALY-MCM, GLYCEROL, ... 著者 Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. 登録日 2020-08-24 公開日 2020-12-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
7JVU	Crystal structure of human histone deacetylase 8 (HDAC8) I45T mutation complexed with SAHA 分子名称: 1,2-ETHANEDIOL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... 著者 Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. 登録日 2020-08-24 公開日 2020-12-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.5004766 Å) 主引用文献 Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
6BVA	Ubiquitin Variant (UbV.Fl10.1) bound to a human Skp1-Fbl10 fragment complex. 分子名称: Lysine-specific demethylase 2B, Polyubiquitin-B, S-phase kinase-associated protein 1 著者 Manczyk, N, Sicheri, F. 登録日 2017-12-12 公開日 2018-07-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure, 26, 2018
6BYH	Ubiquitin Variant (UbV.Fl11.1) bound to a human Skp1-Fbl11 fragment complex. 分子名称: Lysine-specific demethylase 2A, Polyubiquitin-B, S-phase kinase-associated protein 1 著者 Manczyk, N, Sicheri, F. 登録日 2017-12-20 公開日 2018-07-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure, 26, 2018
8FCA	Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate 分子名称: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4 著者 Kwon, D.H, Lee, S.-Y, Zhang, F. 登録日 2022-12-01 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
7K6R	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to GSK4027 分子名称: 1,2-ETHANEDIOL, 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2020-09-21 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem., 18, 2020
7N0A	Structure of Human Leukaemia Inhibitory Factor with Fab MSC1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Leukemia inhibitory factor, ... 著者 Raman, S, Bosch, A, Fransson, J, Julien, J.P. 登録日 2021-05-25 公開日 2022-06-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment. Clin.Cancer Res., 29, 2023
8HBW	Structure of human UCP1 in the ATP-bound state 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CARDIOLIPIN, ... 著者 Chen, L, Kang, Y. 登録日 2022-10-31 公開日 2023-06-21 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (2.57 Å) 主引用文献 Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
7JSA	Crystal structure of the DNA binding domain of human transcription factor ERF in the reduced form, in complex with double-stranded DNA ACCGGAAGTG 分子名称: DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ETS domain-containing transcription factor ERF 著者 Hou, C, Tsodikov, O.V. 登録日 2020-08-14 公開日 2020-11-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural Insight into the DNA Binding Function of Transcription Factor ERF. Biochemistry, 2020
8HBV	Structure of human UCP1 in the nucleotide-free state 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CARDIOLIPIN, Mitochondrial brown fat uncoupling protein 1, ... 著者 Chen, L, Kang, Y. 登録日 2022-10-31 公開日 2023-06-21 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (2.51 Å) 主引用文献 Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
7K6S	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to Compound 4 (SKT1174) 分子名称: (7-amino-3,4-dihydroquinolin-1(2H)-yl)(cyclopropyl)methanone, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Chan, A, Schonbrunn, E. 登録日 2020-09-21 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem., 18, 2020
7JVW	Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, POTASSIUM ION, ... 著者 Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. 登録日 2020-08-24 公開日 2020-12-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.40301776 Å) 主引用文献 Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
4O1Y	Crystal structure of Porcine Pancreatic Phospholipase A2 in complex with 1-Naphthaleneacetic acid 分子名称: CALCIUM ION, NAPHTHALEN-1-YL-ACETIC ACID, Phospholipase A2, ... 著者 Dileep, K.V, Remya, C, Tintu, I, Mandal, P.K, Karthe, P, Haridas, M, Sadasivan, C. 登録日 2013-12-16 公開日 2014-01-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of Porcine Pancreatic Phospholipase A2 in complex with 1-Naphthaleneacetic acid To be published
4P2P	AN INDEPENDENT CRYSTALLOGRAPHIC REFINEMENT OF PORCINE PHOSPHOLIPASE A2 AT 2.4 ANGSTROMS RESOLUTION 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Finzel, B.C, Ohlendorf, D.H, Weber, P.C, Salemme, F.R. 登録日 1991-10-22 公開日 1992-01-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 An independent crystallographic refinement of porcine phospholipase A2 at 2.4 A resolution Acta Crystallogr.,Sect.B, 47, 1991
4FJ3	14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide 分子名称: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase 著者 Ottmann, C, Molzan, M. 登録日 2012-06-11 公開日 2012-09-05 最終更新日 2013-07-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer J.Mol.Biol., 423, 2012
5D1B	Crystal structure of G117E HDAC8 in complex with TSA 分子名称: Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ... 著者 Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2015-08-04 公開日 2015-10-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015

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