PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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4WFX	Coxsackievirus B3 Polymerase - F232L Mutant - NaCl Crystal Form 分子名称: RNA-directed RNA polymerase, SODIUM ION 著者 Peersen, O.B, McDonald, S.M. 登録日 2014-09-17 公開日 2014-10-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.808 Å) 主引用文献 Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases. J.Virol., 89, 2015
2E9R	Foot-and-mouth disease virus RNA-dependent RNA polymerase in complex with a template-primer RNA and with ribavirin 分子名称: 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*CP*CP*C*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2007-01-26 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
2F8E	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with uridylylated VPg protein 分子名称: MAGNESIUM ION, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2005-12-02 公開日 2006-03-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
8IIC	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta40 mutant (residues 41-546) 分子名称: Polymerase polyprotein 著者 Fang, X, Lu, G, Hou, C, Gong, P. 登録日 2023-02-24 公開日 2023-06-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
1HHS	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 分子名称: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. 登録日 2000-12-28 公開日 2001-03-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
1S77	T7 RNAP product pyrophosphate elongation complex 分子名称: DNA (5'-D(*GP*CP*CP*GP*TP*GP*CP*GP*CP*AP*TP*TP*CP*GP*CP*CP*GP*TP*GP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*AP*CP*GP*TP*TP*GP*CP*GP*CP*AP*CP*GP*GP*C)-3'), DNA-directed RNA polymerase, ... 著者 Yin, Y.W, Steitz, T.A. 登録日 2004-01-29 公開日 2004-03-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 The structural mechanism of translocation and helicase activity in T7 RNA polymerase. Cell(Cambridge,Mass.), 116, 2004
4MTP	RdRp from Japanesese Encephalitis Virus 分子名称: RNA dependent RNA polymerase, ZINC ION 著者 Surana, P, Nair, D.T. 登録日 2013-09-20 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
2PI4	T7RNAP complexed with a phi10 protein and initiating GTPs. 分子名称: 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*CP*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', ... 著者 Kennedy, W.P, Momand, J.R, Yin, Y.W. 登録日 2007-04-12 公開日 2007-06-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase. J.Mol.Biol., 370, 2007
2RLU	The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB 分子名称: RNA (5'-R(*GP*GP*UP*UP*GP*CP*GP*GP*GP*UP*CP*UP*CP*GP*CP*AP*AP*CP*C)-3') 著者 Beribisky, A.V, Tavares, T.J, Amborski, A.N, Motamed, M, Johnson, A.E, Mark, T.L, Johnson, P.E. 登録日 2007-08-21 公開日 2008-02-26 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 The three-dimensional structure of the Moorella thermoacetica selenocysteine insertion sequence RNA hairpin and its interaction with the elongation factor SelB Rna, 13, 2007
6VW0	Mycobacterium tuberculosis RNAP S456L mutant open promoter complex 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.59 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6VVX	Mycobacterium tuberculosis WT RNAP transcription initiation intermediate structure with Sorangicin 分子名称: DNA (63-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Boyaci, H, Chen, J, Campbell, E.A, Darst, S.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
7SZK	Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
5K5M	Co-Crystal Structure of Dengue Virus Serotype 2 RNA Dependent RNA Polymerase with Compound 27 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, RNA Dependent RNA Polymerase, ... 著者 Arora, R, Benson, T.E. 登録日 2016-05-23 公開日 2016-08-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling. Plos Pathog., 12, 2016
4IEG	Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 (P1 crystal form) 分子名称: MAGNESIUM ION, RNA-dependent RNA polymerase P2 著者 Ren, Z, Franklin, M.C, Ghose, R. 登録日 2012-12-13 公開日 2013-07-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the RNA-directed RNA Polymerase from the cystovirus 12. Proteins, 81, 2013
3E2E	Crystal Structure of an Intermediate Complex of T7 RNAP and 7nt of RNA 分子名称: DNA (28-MER), DNA (31-MER), DNA-directed RNA polymerase, ... 著者 Durniak, K.J, Bailey, S, Steitz, T.A. 登録日 2008-08-05 公開日 2008-11-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation Science, 322, 2008
6IZZ	The RNA-dependent RNA polymerase domain of dengue 3 NS5, bound with RK-0404678 分子名称: 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, Genome polyprotein, ZINC ION 著者 Shimizu, H, Sekine, S. 登録日 2018-12-20 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
6J00	The RNA-dependent RNA polymerase domain of dengue 3 NS5 分子名称: Genome polyprotein, ZINC ION 著者 Shimizu, H, Sekine, S. 登録日 2018-12-20 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
1TA0	Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand. 分子名称: CITRIC ACID, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, MAGNESIUM ION 著者 Kamenski, T, Heilmeier, S, Meinhart, T, Cramer, P. 登録日 2004-05-19 公開日 2004-08-31 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure and Mechanism of RNA Polymerase II CTD Phosphatases. Mol.Cell, 15, 2004
1T9Z	Three-dimensional structure of a RNA-polymerase II binding protein. 分子名称: CITRIC ACID, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, MAGNESIUM ION 著者 Kamenski, T, Heilmeier, S, Meinhart, A, Cramer, P. 登録日 2004-05-19 公開日 2004-08-31 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure and Mechanism of RNA Polymerase II CTD Phosphatases. Mol.Cell, 15, 2004
6VVZ	Mycobacterium tuberculosis RNAP S456L mutant transcription initiation intermediate structure with Sorangicin 分子名称: DNA (62-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.72 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6VVY	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with Sorangicin 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6OGY	In situ structure of Rotavirus RNA-dependent RNA polymerase at duplex-open state 分子名称: DNA/RNA (5'-D(*(GTG))-R(P*GP*C)-3'), Inner capsid protein VP2, RNA (5'-R(P*AP*GP*CP*C)-3'), ... 著者 Ding, K, Chang, T, Shen, W, Roy, P, Zhou, Z.H. 登録日 2019-04-03 公開日 2019-05-22 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release. Nat Commun, 10, 2019
6M7J	Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin 分子名称: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. 登録日 2018-08-20 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
3H3V	Yeast RNAP II containing poly(A)-signal sequence in the active site 分子名称: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*GP*CP*TP*GP*CP*TP*TP*TP*AP*TP*TP*GP*CP*AP*TP*T)-3', 5'-D(*CP*AP*GP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*UP*CP*GP*CP*AP*AP*UP*AP*AP*A)-3', ... 著者 Dengl, S, Cramer, P. 登録日 2009-04-17 公開日 2009-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Torpedo Nuclease Rat1 Is Insufficient to Terminate RNA Polymerase II in Vitro J.Biol.Chem., 284, 2009
8FPJ	Co-structure of the Human Metapneunomovirus RNA-dependent RNA polymerase with MRK-1 分子名称: 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide, Phosphoprotein, RNA-directed RNA polymerase L 著者 Fischmann, T.O. 登録日 2023-01-04 公開日 2023-06-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.74 Å) 主引用文献 Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol, 6, 2023

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