8FPJ

Co-structure of the Human Metapneunomovirus RNA-dependent RNA polymerase with MRK-1

Summary for 8FPJ

Entry DOI	10.2210/pdb8fpj/pdb
EMDB information	29366
Descriptor	RNA-directed RNA polymerase L, Phosphoprotein, 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide (3 entities in total)
Functional Keywords	rna-binding protein, hmpv, rdrp, rna-dependent rna polymerase, prntase, polyribonucleotidyl transferase, rna capping, viral replication, viral protein, replication
Biological source	Human metapneumovirus More
Total number of polymer chains	5
Total formula weight	374961.97
Authors	Fischmann, T.O. (deposition date: 2023-01-04, release date: 2023-06-14, Last modification date: 2024-06-19)
Primary citation	Kleiner, V.A.,Fischmann, T.O.,Howe, J.A.,Beshore, D.C.,Eddins, M.J.,Hou, Y.,Mayhood, T.,Klein, D.,Nahas, D.D.,Lucas, B.J.,Xi, H.,Murray, E.,Ma, D.Y.,Getty, K.,Fearns, R. Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol, 6:649-649, 2023 Cited by PubMed: 37337079 DOI: 10.1038/s42003-023-04990-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.74 Å)

Structure validation