PDB: 66478 件ウェブページステータス検索Chemie searchBIRD

---

4FAM	Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoic acid (17) 分子名称: 1,2-ETHANEDIOL, 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acid, Aldo-keto reductase family 1 member C3, ... 著者 Turnbull, A.P, Jamieson, S.M.F, Brooke, D.G, Heinrich, D, Atwell, G.J, Silva, S, Hamilton, E.J, Rigoreau, L.J.M, Trivier, E, Soudy, C, Samlal, S.S, Owen, P.J, Schroeder, E, Raynham, T, Flanagan, J.U, Denny, W.A. 登録日 2012-05-22 公開日 2012-10-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3 J.Med.Chem., 55, 2012
5DY5	Crystal structure of human Sirt2 in complex with a SirReal probe fragment 分子名称: (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Rumpf, T, Gerhardt, S, Einsle, O, Jung, M. 登録日 2015-09-24 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure-Based Development of an Affinity Probe for Sirtuin 2. Angew.Chem.Int.Ed.Engl., 55, 2016
5EDM	Crystal structure of prothrombin deletion mutant residues 154-167 ( Form I ) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Pozzi, N, Chen, Z, Di Cera, E. 登録日 2015-10-21 公開日 2016-01-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin. J.Biol.Chem., 291, 2016
5E5F	X-ray structure of the complex between RNase A and compound 4-PF6 ([(PPh3)Au(mi-pbi)Pt(Me)(DMSO)][PF6]), the heterobimetallic derivative obtained in the reaction between the organometallic compound [Pt(pbi)(Me)(DMSO)], pbi=2-(2'-pyridil)benzimidazole (compound 3) and the gold(I) compound [Au(Ph3P)][PF6] 分子名称: ACETATE ION, GOLD ION, Ribonuclease pancreatic, ... 著者 Merlino, A. 登録日 2015-10-08 公開日 2015-12-09 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Cytotoxic properties of a new organometallic platinum(ii) complex and its gold(i) heterobimetallic derivatives. Dalton Trans, 45, 2015
5E5O	I-SmaMI bound to uncleaved DNA target in the presence of Calcium ions 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (25-MER), ... 著者 Shen, B.W. 登録日 2015-10-08 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease. J.Mol.Biol., 428, 2016
4FAL	Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80) 分子名称: 1,2-ETHANEDIOL, 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-N-methylbenzamide, Aldo-keto reductase family 1 member C3, ... 著者 Turnbull, A.P, Jamieson, S.M.F, Brooke, D.G, Heinrich, D, Atwell, G.J, Silva, S, Hamilton, E.J, Rigoreau, L.J.M, Trivier, E, Soudy, C, Samlal, S.S, Owen, P.J, Schroeder, E, Raynham, T, Flanagan, J.U, Denny, W.A. 登録日 2012-05-22 公開日 2012-10-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3 J.Med.Chem., 55, 2012
4F2J	Crystal structure of ZNF217 bound to DNA, P6522 crystal form 分子名称: 5'-D(*TP*TP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', ZINC ION, Zinc finger protein 217 著者 Vandevenne, M.S, Jacques, D.A, Guss, J.M, Mackay, J.P. 登録日 2012-05-08 公開日 2013-02-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217 J.Biol.Chem., 288, 2013
4J75	Crystal Structure of a parasite tRNA synthetase, product-bound 分子名称: GLYCEROL, TRYPTOPHANYL-5'AMP, Tryptophanyl-tRNA synthetase 著者 Koh, C.Y, Kim, J.E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-02-12 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol.Biochem.Parasitol., 189, 2013
4I3E	Crystal structure of Staphylococcal IMPase - I complexed with products. 分子名称: GLYCEROL, Inositol monophosphatase family protein, MAGNESIUM ION, ... 著者 Bhattacharyya, S, Dutta, A, Dutta, D, Das, A.K. 登録日 2012-11-26 公開日 2013-12-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of Staphylococcal IMPase - I complexed with products. To be Published
4I3Y	Crystal structure of Staphylococcal inositol monophosphatase-1: 100 mM LiCl soaked inhibitory complex 分子名称: GLYCEROL, Inositol monophosphatase family protein, MAGNESIUM ION, ... 著者 Dutta, A, Bhattacharyya, S, Dutta, D, Das, A.K. 登録日 2012-11-26 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structural elucidation of the binding site and mode of inhibition of Li(+) and Mg(2+) in inositol monophosphatase. Febs J., 281, 2014
4JWP	Crystal structure of Ribosomal-protein-alanine N-acetyltransferase from Brucella melitensis in complex with Acetyl CoA 分子名称: ACETYL COENZYME *A, CALCIUM ION, CHLORIDE ION, ... 著者 SSGCID, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-03-27 公開日 2013-05-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Ribosomal-protein-alanine N-acetyltransferase from Brucella melitensis in complex with Acetyl CoA TO BE PUBLISHED
4IX0	Computational Design of an Unnatural Amino Acid Metalloprotein with Atomic Level Accuracy 分子名称: NICKEL (II) ION, SULFATE ION, Unnatural Amino Acid Mediated Metalloprotein 著者 Mills, J, Bolduc, J, Khare, S, Stoddard, B, Baker, D. 登録日 2013-01-24 公開日 2013-08-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy. J.Am.Chem.Soc., 135, 2013
4JYS	Crystal structure of FKBP25 from Plasmodium Vivax 分子名称: CHLORIDE ION, IMIDAZOLE, Peptidyl-prolyl cis-trans isomerase 著者 Sreekanth, R, Yoon, H.S. 登録日 2013-04-01 公開日 2014-02-12 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Plasmodium vivax FK506-binding protein 25 reveals conformational changes responsible for its noncanonical activity Proteins, 82, 2014
4TUR	Human DNA polymerase beta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2) 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Cisplatin, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), ... 著者 Koag, M.C, Lee, S. 登録日 2014-06-24 公開日 2014-10-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.169 Å) 主引用文献 Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta. J.Biol.Chem., 289, 2014
2IXF	Crystal structure of the ATPase domain of TAP1 with ATP (D645Q, Q678H mutant) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ANTIGEN PEPTIDE TRANSPORTER 1, GLYCEROL, ... 著者 Procko, E, Ferrin-O'Connell, I, Ng, S.-L, Gaudet, R. 登録日 2006-07-08 公開日 2006-10-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Distinct Structural and Functional Properties of the ATPase Sites in an Asymmetric Abc Transporter. Mol.Cell, 24, 2001
7BEX	Glyceraldehyde 3-phosphate dehydrogenase from Campylobacter jejeuni - ADP complex 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, BETA-MERCAPTOETHANOL, ... 著者 Moody, P.C.E, Ayna, A. 登録日 2020-12-29 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.054 Å) 主引用文献 structure of Camplylobacter jejueni GAPDH in complex with ADP To Be Published
4BI8	Crystal structure of the type VI effector-immunity complex Ssp1-Rap1a from Serratia marcescens 分子名称: RAP1A, SSSP1 著者 Srikannathasan, V, Coulthurst, S.J, Hunter, W.N. 登録日 2013-04-09 公開日 2013-06-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Type Vi Secreted Peptidoglycan Dl-Endopeptidase Function, Specificity and Neutralization in Serratia Marcescens Acta Crystallogr.,Sect.D, 69, 2013
4XBJ	Y274F alanine racemase from E. coli inhibited by l-ala-p 分子名称: Alanine racemase, biosynthetic, SULFATE ION, ... 著者 Squire, C.J, Yosaatmadja, Y, Patrick, W.M. 登録日 2014-12-17 公開日 2015-12-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J.Biol.Chem., 291, 2016
4TY1	Crystal structure of human Pim-1 kinase in complex with an aminooxadiazole-indole inhibitor. 分子名称: GLYCEROL, N-tert-butyl-5-[3-(4-cyclopropylpyrimidin-2-yl)-1H-indol-5-yl]-1,3,4-oxadiazol-2-amine, Serine/threonine-protein kinase pim-1 著者 Mohr, C. 登録日 2014-07-07 公開日 2015-02-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4UBC	DNA polymerase beta substrate complex with a templating cytosine and incoming 8-oxodGTP, 0 s 分子名称: 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... 著者 Freudenthal, B.D, Wilson, S.H, Beard, W.A. 登録日 2014-08-12 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature, 517, 2015
4TUF	Catalytic domain of the major endoglucanase from Xanthomonas campestris pv. campestris 分子名称: DIHYDROGENPHOSPHATE ION, Major extracellular endoglucanase 著者 Puhl, A.C, Rosseto, F.R, Polikarpov, I. 登録日 2014-06-24 公開日 2015-10-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Substrate cleavage pattern, biophysical characterization and crystallographic structure of the major endoglucanase from Xanthomonas campestris pv. campestris To Be Published
4TZA	TGP, an extremely thermostable green fluorescent protein created by structure-guided surface engineering 分子名称: Fluorescent Protein 著者 Close, D.W, Bradbury, A.R.M. 登録日 2014-07-09 公開日 2014-10-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering. Proteins, 83, 2015
4BI3	Structure and function of amidase toxin - antitoxin combinations associated with the type VI secretion system of Serratia marcescens. 分子名称: POTASSIUM ION, SSP1, SULFATE ION 著者 Srikannathasan, V, English, G, Bui, N.K, Trunk, K, Rourke, P.E.F.O, Rao, V.A, Vollmer, W, Coulthurst, S.J, Hunter, W.N. 登録日 2013-04-09 公開日 2013-06-19 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Basis for Type Vi Secreted Peptidoglycan Dl-Endopeptidase Function, Specificity and Neutralization in Serratia Marcescens Acta Crystallogr.,Sect.D, 69, 2013
4K3Q	E. coli sliding clamp in complex with AcQLDAF 分子名称: (ACE)QLDAF, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Yin, Z, Oakley, A.J. 登録日 2013-04-11 公開日 2013-05-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp J.Med.Chem., 56, 2013
2YDJ	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas 分子名称: 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, PHOSPHATE ION, SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Read, J.A, Breed, J, Haye, H, McCall, E, Rowsell, S, Vallentine, A, White, A. 登録日 2011-03-22 公開日 2012-01-25 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(Piperidin-3-Yl)-3-Ureidothiophene-2-Carboxamide (Azd7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas. J.Med.Chem., 55, 2012

<262263264265266267268269270271272273274275276277>