6GXB

Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13

Summary for 6GXB

Entry DOI	10.2210/pdb6gxb/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, ~{N}-[4-[4-[(4-sulfamoylphenyl)carbamoylamino]phenoxy]butyl]ethanamide, ... (4 entities in total)
Functional Keywords	carbonic anhydrase, caii mutant to caix mimic, ca inhibitor, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29330.36
Authors	Brynda, J.,Rezacova, P.,Pospisilova, K. (deposition date: 2018-06-27, release date: 2019-05-08, Last modification date: 2024-01-17)
Primary citation	Pospisilova, K.,Knedlik, T.,Brynda, J.,Rezacova, P.,Sacha, P.,Schimer, J.,Kral, V.,Cigler, P.,Navratil, V.,Subr, V.,Konvalinka, J. Inhibitor-Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms Acs Omega, 4:6746-6756, 2019 Cited by DOI: 10.1021/acsomega.9b00596 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation