6GXB
Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 2 | polymer | 257 | 28844.5 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | ~{N}-[4-[4-[(4-sulfamoylphenyl)carbamoylamino]phenoxy]butyl]ethanamide | non-polymer | 420.5 | 1 | Chemie (FF5) | |||
| 4 | D (A) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A: 4 - 260 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | conflict |
| Gln 67 | Asn 67 | conflict |
| Thr 69 | Glu 69 | conflict |
| Leu 91 | Ile 91 | conflict |
| Val 130 | Phe 130 | conflict |
| Glu 169 | Lys 169 | conflict |
| Ala 203 | Leu 203 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28844.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 485.9 | |
| All* | Total formula weight | 29330.4 |
