5F9T

Crystal Structure of Streptococcus pneumoniae NanC, covalent complex with a fluorinated Neu5Ac derivative

Replaces:  4YW0

Summary for 5F9T

• Entry DOI: 10.2210/pdb5f9t/pdb
• Descriptor: Neuraminidase C, 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, (2R,3R,4R,5R,6R)-5-acetamido-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylic acid, ... (5 entities in total)
• Functional Keywords: sialidase, neuraminidase, covalent intermediate, cbm40, hydrolase
• Biological source: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
• Total number of polymer chains: 2
• Total formula weight: 149362.33

Authors

Owen, C.D.,Lukacik, P.,Potter, J.A.,Walsh, M.,Taylor, G.L. (deposition date: 2015-12-10, release date: 2015-12-23, Last modification date: 2024-01-10)

• Primary citation: Owen, C.D.,Lukacik, P.,Potter, J.A.,Sleator, O.,Taylor, G.L.,Walsh, M.A.; Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.; J.Biol.Chem., 290:27736-27748, 2015; PubMed: 26370075; DOI: 10.1074/jbc.M115.673632

Experimental method

X-RAY DIFFRACTION (2.05 Å)