3RGH
 
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5L6W
 | | Structure Of the LIMK1-ATPgammaS-CFL1 Complex | | 分子名称: | Cofilin-1, LIM domain kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Salah, E, Mathea, S, Oerum, S, Newman, J.A, Tallant, C, Adamson, R, Canning, P, Beltrami, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Bullock, A.N. | | 登録日 | 2016-05-31 | | 公開日 | 2016-06-08 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Structure Of the LIMK1-ATPgammaS-CFL1 Complex
To Be Published
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6OSM
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6OSJ
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6OSL
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6PES
 | | Cryo-EM structure of alpha-synuclein H50Q Wide Fibril | | 分子名称: | Alpha-synuclein | | 著者 | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | | 登録日 | 2019-06-20 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
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6PCV
 | | Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 | | 著者 | Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. | | 登録日 | 2019-06-18 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
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6PEO
 | | Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril | | 分子名称: | Alpha-synuclein | | 著者 | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | | 登録日 | 2019-06-20 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
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1YBO
 | | Crystal structure of the PDZ tandem of human syntenin with syndecan peptide | | 分子名称: | Syndecan-4, Syntenin 1 | | 著者 | Grembecka, J, Cooper, D.R, Cierpicki, T, Kang, B.S, Devedjiev, Y, Derewenda, Z. | | 登録日 | 2004-12-21 | | 公開日 | 2006-01-10 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The binding of the PDZ tandem of syntenin to target proteins
Biochemistry, 45, 2006
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8T9D
 | | CryoEM structure of TR-TRAP | | 分子名称: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | | 著者 | Zhao, H, Asturias, F. | | 登録日 | 2023-06-23 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (4.66 Å) | | 主引用文献 | An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.
Mol.Cell, 84, 2024
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8Q0N
 | | HACE1 in complex with RAC1 Q61L | | 分子名称: | E3 ubiquitin-protein ligase HACE1, GUANOSINE-5'-TRIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ... | | 著者 | Wolter, M, Duering, J, Dienemann, C, Lorenz, S. | | 登録日 | 2023-07-28 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1.
Nat.Struct.Mol.Biol., 31, 2024
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5N6O
 | | Wild type human Rac1-GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Cherfils, J, Ferrandez, Y. | | 登録日 | 2017-02-15 | | 公開日 | 2017-12-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.
Sci Rep, 7, 2017
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8T1D
 | | Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD | | 分子名称: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-06-02 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
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8T1F
 | | Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-06-02 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
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8T1B
 | | Cryo-EM structure of full-length human TRPV4 in apo state | | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, ... | | 著者 | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-06-02 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
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8T1E
 | | Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD | | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ... | | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-06-02 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
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4P3W
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8J07
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6X1G
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3EEB
 | | Structure of the V. cholerae RTX cysteine protease domain | | 分子名称: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION | | 著者 | Lupardus, P.J, Shen, A, Bogyo, M, Garcia, K.C. | | 登録日 | 2008-09-04 | | 公開日 | 2008-10-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain
Science, 322, 2008
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3F7R
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8T1I
 | | Atomic model of the mammalian Mediator complex with MED26 subunit | | 分子名称: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | | 著者 | Zhao, H, Asturias, F. | | 登録日 | 2023-06-02 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (4.68 Å) | | 主引用文献 | An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.
Mol.Cell, 84, 2024
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8T1L
 | | Atomic model of the mammalian mouse Mediator complex with CKM module | | 分子名称: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | | 著者 | Zhao, H, Asturias, F. | | 登録日 | 2023-06-02 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4.83 Å) | | 主引用文献 | A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.
To Be Published
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8HLP
 | | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Wei, Y, Yu, Z, Zhao, Y. | | 登録日 | 2022-11-30 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors.
Nat Commun, 15, 2024
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6NAJ
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