8DNE
 
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7V8L
 | | LolCDE with bound RcsF in nanodiscs | | 分子名称: | (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, ... | | 著者 | Bei, W.W, Luo, Q.S, Shi, H.G, Zhang, X.Z, Huang, Y.H. | | 登録日 | 2021-08-23 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli.
Plos Biol., 20, 2022
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8EJ1
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8EIG
 | | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445) and ATP/Mg | | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | 著者 | Fiedorczuk, K, Chen, J. | | 登録日 | 2022-09-15 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
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8EIQ
 | | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg | | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | 著者 | Fiedorczuk, K, Chen, J. | | 登録日 | 2022-09-15 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
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8EIO
 | | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg | | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | 著者 | Fiedorczuk, K, Chen, J. | | 登録日 | 2022-09-15 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
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7V5C
 | | Cryo-EM structure of the mouse ABCB9 (ADP.BeF3-bound) | | 分子名称: | ABC-type oligopeptide transporter ABCB9, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Park, J.G, Kim, S, Jang, E, Choi, S.H, Han, H, Kim, J.W, Ju, S, Min, D.S, Jin, M.S. | | 登録日 | 2021-08-17 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.
Nat Commun, 13, 2022
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7V5D
 | | Cryo-EM structure of the mouse ABCB9 (PG-bound) | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ABC-type oligopeptide transporter ABCB9 | | 著者 | Park, J.G, Kim, S, Jang, E, Choi, S.H, Han, H, Ju, S, Kim, J.W, Min, D.S, Jin, M.S. | | 登録日 | 2021-08-17 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.
Nat Commun, 13, 2022
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7VFI
 | | Cryo-EM structure of the mouse TAPL (9mer-peptide bound) | | 分子名称: | ABC-type oligopeptide transporter ABCB9, ARG-ARG-TYR-GLN-LYS-SER-THR-GLU-LEU, CHOLESTEROL HEMISUCCINATE | | 著者 | Park, J.G, Kim, S, Jang, E, Choi, S.H, Han, H, Kim, J.W, Ju, S, Min, D.S, Jin, M.S. | | 登録日 | 2021-09-13 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | | 主引用文献 | The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.
Nat Commun, 13, 2022
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7SH1
 | | Class II UvrA protein - Ecm16 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Excinuclease ABC subunit UvrA, ... | | 著者 | Grade, P, Erlandson, A, Ullah, A, Mathews, I.I, Chen, X, Kim, C.-Y, Mera, P.E. | | 登録日 | 2021-10-07 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structural and functional analyses of the echinomycin resistance conferring protein Ecm16 from Streptomyces lasalocidi.
Sci Rep, 13, 2023
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7QKS
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7QKR
 | | Cryo-EM structure of ABC transporter STE6-2p from Pichia pastoris with Verapamil at 3.2 A resolution | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Dexverapamil, MAGNESIUM ION, ... | | 著者 | Schleker, E.S.M, Reinhart, C. | | 登録日 | 2021-12-18 | | 公開日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VR1
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7O0Z
 | | ABC transporter NosFY, nucleotide-free in GDN | | 分子名称: | Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter permease protein NosY | | 著者 | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | | 登録日 | 2021-03-28 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Molecular interplay of an assembly machinery for nitrous oxide reductase.
Nature, 608, 2022
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7O13
 | | ABC transporter NosDFY, nucleotide-free in lipid nanodisc | | 分子名称: | MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter binding protein NosD, ... | | 著者 | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | | 登録日 | 2021-03-28 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular interplay of an assembly machinery for nitrous oxide reductase.
Nature, 608, 2022
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7VFJ
 | | Cytochrome c-type biogenesis protein CcmABCD | | 分子名称: | Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, Heme exporter protein C, ... | | 著者 | Zhu, J.P, Zhang, K, Li, J, Zheng, W, Gu, M. | | 登録日 | 2021-09-13 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7VFP
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | 登録日 | 2021-09-13 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7F02
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | 登録日 | 2021-06-03 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7F03
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with ANP | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | 登録日 | 2021-06-03 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7F04
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with Heme and ATP. | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, ... | | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | 登録日 | 2021-06-03 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7WIT
 | | Structure of SUR1 in complex with mitiglinide | | 分子名称: | (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1 | | 著者 | Chen, L, Wang, M.M. | | 登録日 | 2022-01-04 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Front Pharmacol, 13, 2022
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7ZOA
 | | cryo-EM structure of CGT ABC transporter in presence of CBG substrate | | 分子名称: | Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, Cyclooctadecakis-(1-2)-(beta-D-glucopyranose) | | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | | 登録日 | 2022-04-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella.
Nat.Struct.Mol.Biol., 29, 2022
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7ZO8
 | | cryo-EM structure of CGT ABC transporter in nanodisc apo state | | 分子名称: | Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, DIUNDECYL PHOSPHATIDYL CHOLINE | | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | | 登録日 | 2022-04-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella.
Nat.Struct.Mol.Biol., 29, 2022
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7ZO9
 | | cryo-EM structure of CGT ABC transporter in vanadate trapped state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, VANADATE ION | | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | | 登録日 | 2022-04-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella.
Nat.Struct.Mol.Biol., 29, 2022
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8DHY
 | | N-terminal fragment of MsbA fused to GFP in complex with copper(II) | | 分子名称: | COPPER (II) ION, Fusion protein of MsbA N-terminal fragment and GFP,Green fluorescent protein | | 著者 | Schrecke, S.R, Zhang, T, Lyu, J, Laganowsky, A. | | 登録日 | 2022-06-28 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural basis for lipid and copper regulation of the ABC transporter MsbA.
Nat Commun, 13, 2022
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