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7M2I
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Structural Snapshots of Intermediates in the Gating of a K+ Channel
分子名称: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Monoclonal antibody (IgG) against KcsA, Fab heavy chain, ...
著者Reddi, R, Valiyaveetil, F.I.
登録日2021-03-16
公開日2021-10-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.695 Å)
主引用文献Structures of Gating Intermediates in a K + channell.
J.Mol.Biol., 433, 2021
7M7E
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6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2
分子名称: 1B2 (heavy chain), 1B2 (light chain), 6-deoxyerythronolide-B synthase EryA2, ...
著者Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
登録日2021-03-28
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7G
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6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 2
分子名称: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
著者Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
登録日2021-03-28
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7H
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6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1'
分子名称: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
著者Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
登録日2021-03-28
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7I
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6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2 (TE-free)
分子名称: 1B2 (heavy chain), 1B2 (light chain), EryAI, ...
著者Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
登録日2021-03-28
公開日2021-11-17
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7J
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6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: "turnstile closed" state (TE-free)
分子名称: 1B2 (heavy chain), 1B2 (light chain), EryAI
著者Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
登録日2021-03-28
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7F
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6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1
分子名称: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
著者Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
登録日2021-03-28
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7PIU
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Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution.
分子名称: CALCIUM ION, Camelid antibody fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P.
登録日2021-08-23
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (2.58 Å)
主引用文献Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Cell Res., 31, 2021
7PIV
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Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution.
分子名称: CALCIUM ION, Camelid antibody VHH fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P.
登録日2021-08-23
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Cell Res., 31, 2021
7LI9
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BU of 7li9 by Molmil
5-HT bound serotonin transporter reconstituted in lipid nanodisc in KCl
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ...
著者Yang, D, Gouaux, E.
登録日2021-01-26
公開日2021-12-15
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Illumination of serotonin transporter mechanism and role of the allosteric site.
Sci Adv, 7, 2021
7LIA
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5-HT bound serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in outward facing conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ...
著者Yang, D, Gouaux, E.
登録日2021-01-26
公開日2021-12-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Illumination of serotonin transporter mechanism and role of the allosteric site.
Sci Adv, 7, 2021
5WCD
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BU of 5wcd by Molmil
Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 04-1D02 Fab.
分子名称: PHOSPHATE ION, SULFATE ION, VRC315 04-1D02 Fab Heavy chain, ...
著者Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D.
登録日2017-06-29
公開日2017-08-23
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (1.814 Å)
主引用文献Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Sci Immunol, 2, 2017
7LJ5
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BU of 7lj5 by Molmil
Human TRAAK K+ channel FHIEG mutant A198E in a K+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Rietmeijer, R.A, Brohawn, S.G.
登録日2021-01-28
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK.
Neuron, 109, 2021
7LJB
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Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Rietmeijer, R.A, Brohawn, S.G.
登録日2021-01-28
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK.
Neuron, 109, 2021
7LJA
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BU of 7lja by Molmil
Human TRAAK K+ channel FHEIG mutant A198E in a Tl+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Rietmeijer, R.A, Brohawn, S.G.
登録日2021-01-28
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK.
Neuron, 109, 2021
7LJ4
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BU of 7lj4 by Molmil
Human TRAAK K+ channel FHEIG mutant A270P in a K+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Rietmeijer, R.A, Brohawn, S.G.
登録日2021-01-28
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.782 Å)
主引用文献Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK.
Neuron, 109, 2021
7VAF
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BU of 7vaf by Molmil
Cryo-EM structure of Rat NTCP complexed with YN69202Fab
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
著者Asami, J, Shimizu, T, Ohto, U.
登録日2021-08-29
公開日2022-05-25
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAG
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Cryo-EM structure of human NTCP complexed with YN69202Fab in the presence of myristoylated preS1 peptide
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
著者Asami, J, Shimizu, T, Ohto, U.
登録日2021-08-29
公開日2022-05-25
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAD
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Cryo-EM structure of human NTCP complexed with YN69202Fab
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
著者Asami, J, Shimizu, T, Ohto, U.
登録日2021-08-29
公開日2022-05-25
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAE
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BU of 7vae by Molmil
Cryo-EM structure of bovine NTCP complexed with YN69202Fab
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ...
著者Asami, J, Shimizu, T, Ohto, U.
登録日2021-08-29
公開日2022-05-25
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.55 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
5VGA
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Alternative model for Fab 36-65
分子名称: Fab 36-65 heavy chain, Fab 36-65 light chain, TRIETHYLENE GLYCOL
著者Stanfield, R.L, Rupp, B, Wlodawer, A, Dauter, Z, Porebski, P.J, Minor, W, Jaskolski, M, Pozharski, E, Weichenberger, C.X.
登録日2017-04-10
公開日2017-12-06
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Detect, correct, retract: How to manage incorrect structural models.
FEBS J., 285, 2018
2Y7S
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Structure of a designed meningococcal antigen (factor H binding protein, mutant G1) inducing broad protective immunity
分子名称: FACTOR H BINDING PROTEIN
著者Malito, E, Spraggon, G, Bottomley, M.J.
登録日2011-02-01
公開日2011-07-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity.
Sci.Transl.Med, 3, 2011
2MCP
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REFINED CRYSTAL STRUCTURE OF THE MC/PC603 FAB-PHOSPHOCHOLINE COMPLEX AT 3.1 ANGSTROMS RESOLUTION
分子名称: IGA-KAPPA MCPC603 FAB (HEAVY CHAIN), IGA-KAPPA MCPC603 FAB (LIGHT CHAIN), PHOSPHOCHOLINE
著者Padlan, E.A, Cohen, G.H, Davies, D.R.
登録日1984-10-15
公開日1985-01-02
最終更新日2023-07-26
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Refined Crystal Structure of the Mc/Pc603 Fab-Phosphocholine Complex at 3.1 Angstroms Resolution
To be Published
5WCA
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BU of 5wca by Molmil
Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 27-1C08 Fab.
分子名称: VRC315 27-1C08 Fab Heavy chain, VRC315 27-1C08 Fab Light chain
著者Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D.
登録日2017-06-29
公開日2017-08-02
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.369 Å)
主引用文献Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Sci Immunol, 2, 2017
7O7F
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BU of 7o7f by Molmil
Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
分子名称: C-C chemokine receptor type 5, C-C motif chemokine 5, Fab antibody fragment heavy chain, ...
著者Isaikina, P, Tsai, C.-J, Dietz, N.B, Pamula, F, Goldie, K.N, Schertler, G.F.X, Maier, T, Stahlberg, H, Deupi, X, Grzesiek, S.
登録日2021-04-13
公開日2021-06-30
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist.
Sci Adv, 7, 2021

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