PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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6CKC	Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity 分子名称: 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 Antonysamy, S. 登録日 2018-02-27 公開日 2018-05-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med Chem Lett, 9, 2018
8Y0X	Dormant ribosome with SERBP1 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Du, M, Zeng, F. 登録日 2024-01-23 公開日 2024-02-07 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The global structure of dormant ribosome To Be Published
6R6G	Structure of XBP1u-paused ribosome nascent chain complex with SRP. 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. 登録日 2019-03-27 公開日 2019-07-10 最終更新日 2019-10-30 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
8XXM	Cryo-EM structure of the human 40S ribosome with PDCD4 and eIF3G 分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. 登録日 2024-01-18 公開日 2024-05-01 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
6IKA	HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:entecavir-triphosphate ternary complex 分子名称: DNA/RNA (38-MER), GLYCEROL, HIV-1 RT p51 subunit, ... 著者 Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. 登録日 2018-10-15 公開日 2019-01-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.598 Å) 主引用文献 Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors. Biochem. Biophys. Res. Commun., 509, 2019
6IK9	HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:dGTP ternary complex 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ... 著者 Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. 登録日 2018-10-15 公開日 2019-01-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.435 Å) 主引用文献 Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors. Biochem. Biophys. Res. Commun., 509, 2019
1T3W	Crystal Structure of the E.coli DnaG C-terminal domain (residues 434 to 581) 分子名称: ACETIC ACID, DNA primase 著者 Oakley, A.J, Loscha, K.V, Schaeffer, P.M, Liepinsh, E, Wilce, M.C.J, Otting, G, Dixon, N.E. 登録日 2004-04-28 公開日 2004-11-02 最終更新日 2016-09-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal and solution structures of the helicase-binding domain of Escherichia coli primase J.Biol.Chem., 280, 2005
6R5Q	Structure of XBP1u-paused ribosome nascent chain complex (post-state) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2019-03-25 公開日 2019-07-10 最終更新日 2019-10-30 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
6R7Q	Structure of XBP1u-paused ribosome nascent chain complex with Sec61. 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. 登録日 2019-03-29 公開日 2019-07-10 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
8BTK	Structure of the TRAP complex with the Sec translocon and a translating ribosome 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... 著者 Jaskolowski, M, Jomaa, A, Gamerdinger, M, Shrestha, S, Leibundgut, M, Deuerling, E, Ban, N. 登録日 2022-11-29 公開日 2023-05-24 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Molecular basis of the TRAP complex function in ER protein biogenesis. Nat.Struct.Mol.Biol., 30, 2023
6R6P	Structure of XBP1u-paused ribosome nascent chain complex (rotated state) 分子名称: 18S rRNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2019-03-27 公開日 2019-07-10 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
5AJ0	Cryo electron microscopy of actively translating human polysomes (POST state). 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Behrmann, E, Loerke, J, Budkevich, T.V, Yamamoto, K, Schmidt, A, Penczek, P.A, Vos, M.R, Burger, J, Mielke, T, Scheerer, P, Spahn, C.M.T. 登録日 2015-02-19 公開日 2015-05-20 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural Snapshots of Actively Translating Human Ribosomes Cell(Cambridge,Mass.), 161, 2015
8XXL	Cryo-EM structure of the human 40S ribosome with PDCD4 分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. 登録日 2024-01-18 公開日 2024-05-01 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
6W38	Crystal structure of the FAM46C/Plk4 complex 分子名称: Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C 著者 Chen, H, Lu, D.F, Shang, G.J, Zhang, X.W. 登録日 2020-03-09 公開日 2020-05-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (4.48 Å) 主引用文献 Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure, 28, 2020
6W3J	Crystal structure of the FAM46C/Plk4/Cep192 complex 分子名称: Centrosomal protein of 192 kDa, Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C 著者 Chen, H, Lu, D.F, Shang, G.J, Zhang, X.W. 登録日 2020-03-09 公開日 2020-05-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (4.385 Å) 主引用文献 Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure, 28, 2020
6W36	Crystal structure of FAM46C 分子名称: SULFATE ION, Terminal nucleotidyltransferase 5C 著者 Shang, G.J, Zhang, X.W, Chen, H, Lu, D.F. 登録日 2020-03-09 公開日 2020-05-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.854 Å) 主引用文献 Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure, 28, 2020
7ZWA	CryoEM structure of Ku heterodimer bound to DNA and PAXX 分子名称: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3'), PHOSPHATE ION, ... 著者 Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. 登録日 2022-05-19 公開日 2023-05-31 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
7ZYG	CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF 分子名称: DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ... 著者 Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. 登録日 2022-05-24 公開日 2023-06-07 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
3ZOB	Solution structure of chicken Engrailed 2 homeodomain 分子名称: HOMEOBOX PROTEIN ENGRAILED-2 著者 Carlier, L, Balayssac, S, Cantrelle, F.X, Khemtemourian, L, Chassaing, G, Joliot, A, Lequin, O. 登録日 2013-02-21 公開日 2013-08-28 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Investigation of Homeodomain Membrane Translocation Properties: Insights from the Structure Determination of Engrailed-2 Homeodomain in Aqueous and Membrane-Mimetic Environments. Biophys.J., 105, 2013
7QWR	Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC 分子名称: 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Jomaa, A, Gamerdinger, M, Hsieh, H, Wallisch, A, Chandrasekaran, V, Ulusoy, Z, Scaiola, A, Hegde, R, Shan, S, Ban, N, Deuerling, E. 登録日 2022-01-25 公開日 2022-03-09 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science, 375, 2022
7CPV	Cryo-EM structure of 80S ribosome from mouse testis 分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ... 著者 Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H. 登録日 2020-08-08 公開日 2022-02-02 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 A male germ-cell-specific ribosome controls male fertility. Nature, 612, 2022
7CPU	Cryo-EM structure of 80S ribosome from mouse kidney 分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ... 著者 Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H. 登録日 2020-08-08 公開日 2022-02-02 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.82 Å) 主引用文献 A male germ-cell-specific ribosome controls male fertility. Nature, 612, 2022
5BTH	Crystal structure of Candida albicans Rai1 分子名称: Decapping nuclease RAI1 著者 Wang, V.Y, Tong, L. 登録日 2015-06-03 公開日 2015-07-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes. Nucleic Acids Res., 43, 2015
1JLU	Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Phosphorylated Substrate Peptide and Detergent 分子名称: AMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ... 著者 Madhusudan, Trafny, E.A, Xuong, N.-H, Adams, J.A, Ten Eyck, L.F, Taylor, S.S, Sowadski, J.M. 登録日 2001-07-16 公開日 2001-08-01 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci., 3, 1994
5UQ3	Crystal structure of human Cdk2-Spy1-P27 ternary complex 分子名称: Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, Speedy protein A 著者 McGrath, D.A, Tripathi, S.M, Rubin, S.M. 登録日 2017-02-06 公開日 2017-07-05 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017

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