1ZT2
 
 | | Heterodimeric structure of the core primase. | | 分子名称: | DNA primase large subunit, DNA primase small subunit, SULFATE ION, ... | | 著者 | Lao-Sirieix, S.H, Nookala, R.K, Roversi, P, Bell, S.D, Pellegrini, L. | | 登録日 | 2005-05-26 | | 公開日 | 2005-11-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Structure of the heterodimeric core primase.
Nat.Struct.Mol.Biol., 12, 2005
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4XWJ
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3QAZ
 | | IL-2 mutant D10 ternary complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-2, ... | | 著者 | Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Gathman, C.G, Garcia, K.C. | | 登録日 | 2011-01-12 | | 公開日 | 2012-04-11 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.802 Å) | | 主引用文献 | Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Nature, 484, 2012
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5O1W
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8KI6
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6XTE
 | | Human karyopherin RanBP5 (isoform-1) | | 分子名称: | Antipain, CHLORIDE ION, Importin-5, ... | | 著者 | Swale, C, McCarthy, A.A, Ruigrok, R.W.H, Crepin, T. | | 登録日 | 2020-01-16 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
J.Mol.Biol., 432, 2020
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5O1X
 | | Structure of Nrd1 RNA binding domain | | 分子名称: | 1,2-ETHANEDIOL, Protein NRD1, THIOCYANATE ION | | 著者 | Franco-Echevarria, E, Perez-Canadillas, J.M, Gonzalez, B. | | 登録日 | 2017-05-19 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition.
Nucleic Acids Res., 45, 2017
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2JZ3
 | | SOCS box elonginBC ternary complex | | 分子名称: | Suppressor of cytokine signaling 3, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2 | | 著者 | Babon, J.J, Sabo, J, Soetopo, A, Yao, S, Bailey, M.F, Zhang, J, Nicola, N.A, Norton, R.S. | | 登録日 | 2007-12-27 | | 公開日 | 2008-09-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase
J.Mol.Biol., 381, 2008
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4C0B
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7SSG
 | | Mfd DNA complex | | 分子名称: | DNA (5'-D(P*TP*GP*GP*CP*GP*GP*CP*GP*AP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*GP*CP*CP*TP*CP*GP*CP*TP*GP*CP*CP*A)-3'), Transcription-repair-coupling factor | | 著者 | Oakley, A.J, Xu, Z.-Q. | | 登録日 | 2021-11-11 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | | 主引用文献 | Mechanism of transcription modulation by the transcription-repair coupling factor.
Nucleic Acids Res., 50, 2022
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7OXU
 | | VDR complex - calcitroic acid | | 分子名称: | Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor A, calcitroic acid | | 著者 | Rochel, N, Arnold, L.A. | | 登録日 | 2021-06-23 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | VDR complex - calcitroic acid
To Be Published
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8FLK
 | | Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2 | | 分子名称: | 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, cGAMP | | 著者 | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | | 登録日 | 2022-12-21 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Activation of human STING by a molecular glue-like compound.
Nat.Chem.Biol., 20, 2024
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8FLM
 | | Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53 | | 分子名称: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, ... | | 著者 | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | | 登録日 | 2022-12-21 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Activation of human STING by a molecular glue-like compound.
Nat.Chem.Biol., 20, 2024
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8FLI
 | | Cryo-EM structure of a group II intron immediately before branching | | 分子名称: | Group II Intron, MAGNESIUM ION, Maturase reverse transcriptase | | 著者 | Haack, D.B, Rudolfs, B.G, Zhang, C, Lyumkis, D, Toor, N. | | 登録日 | 2022-12-21 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of branching during RNA splicing.
Nat.Struct.Mol.Biol., 31, 2024
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8UO1
 | | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class Q) | | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
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3PQY
 | | Crystal Structure of 6218 TCR in complex with the H2Db-PA224 | | 分子名称: | 10-mer peptide from RNA-directed RNA polymerase, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | | 著者 | Gras, S, Guillonneau, C, Turner, S.J, Rossjohn, J. | | 登録日 | 2010-11-28 | | 公開日 | 2011-05-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.192 Å) | | 主引用文献 | Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses
Proc.Natl.Acad.Sci.USA, 108, 2011
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6OD9
 | | Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser | | 分子名称: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, CESIUM ION, MAGNESIUM ION, ... | | 著者 | Jones, C.P, Tran, B, Ferre-D'Amare, A.R. | | 登録日 | 2019-03-26 | | 公開日 | 2019-07-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (4.102 Å) | | 主引用文献 | Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser.
Acta Crystallogr.,Sect.F, 75, 2019
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8TW4
 | | TCR in nanodisc ND-I | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Notti, R.Q, Walz, T. | | 登録日 | 2023-08-20 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex.
Biorxiv, 2024
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4OY2
 | | Crystal structure of TAF1-TAF7, a TFIID subcomplex | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 7, ... | | 著者 | Bhattacharya, S, Lou, X, Rajashankar, K, Jacobson, R.H, Webb, P. | | 登録日 | 2014-02-10 | | 公開日 | 2014-06-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4EJS
 | | Structure of yeast elongator subcomplex Elp456 | | 分子名称: | Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6 | | 著者 | Lin, Z, Zhao, W, Long, J, Shen, Y. | | 登録日 | 2012-04-07 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.606 Å) | | 主引用文献 | Crystal structure of elongator subcomplex Elp4-6
J.Biol.Chem., 287, 2012
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4LIM
 | | Crystal structure of the catalytic subunit of yeast primase | | 分子名称: | DNA primase small subunit, ZINC ION | | 著者 | Vaithiyalingam, S, Chazin, W.J, Berger, J.M, Corn, J, Stephenson, S. | | 登録日 | 2013-07-02 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase.
J.Mol.Biol., 426, 2014
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2K7L
 | | NMR structure of a complex formed by the C-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 | | 分子名称: | General transcription factor IIF subunit 1, centFCP1-T584PO4 peptide | | 著者 | Yang, A, Abbott, K.L, Desjardins, A, Di Lello, P, Omichinski, J.G, Legault, P. | | 登録日 | 2008-08-13 | | 公開日 | 2009-06-02 | | 最終更新日 | 2020-02-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase
Biochemistry, 48, 2009
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4F7T
 | | Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PB1 (498-505) | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | | 著者 | Liu, J, Zhang, S, Tan, S, Yi, Y, Wu, B, Zhu, F, Wang, H, Qi, J, Gao, G.F. | | 登録日 | 2012-05-16 | | 公開日 | 2012-10-10 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals.
J.Virol., 86, 2012
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6IG1
 | | DNA polymerase IV - DNA ternary complex 10 | | 分子名称: | DIPHOSPHATE, DNA polymerase IV, DTN3, ... | | 著者 | Kottur, J, Nair, D.T. | | 登録日 | 2018-09-21 | | 公開日 | 2018-11-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction.
Nucleic Acids Res., 46, 2018
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5V37
 | | Crystal structure of SMYD3 with SAM and EPZ028862 | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | Boriack-Sjodin, P.A. | | 登録日 | 2017-03-06 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
Plos One, 13, 2018
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