5V37
Crystal structure of SMYD3 with SAM and EPZ028862
Summary for 5V37
Entry DOI | 10.2210/pdb5v37/pdb |
Related | 5V3H |
Descriptor | Histone-lysine N-methyltransferase SMYD3, ZINC ION, S-ADENOSYLMETHIONINE, ... (8 entities in total) |
Functional Keywords | protein-inhibitor complex, protein lysine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 50615.90 |
Authors | Boriack-Sjodin, P.A. (deposition date: 2017-03-06, release date: 2018-03-07, Last modification date: 2024-03-06) |
Primary citation | Thomenius, M.J.,Totman, J.,Harvey, D.,Mitchell, L.H.,Riera, T.V.,Cosmopoulos, K.,Grassian, A.R.,Klaus, C.,Foley, M.,Admirand, E.A.,Jahic, H.,Majer, C.,Wigle, T.,Jacques, S.L.,Gureasko, J.,Brach, D.,Lingaraj, T.,West, K.,Smith, S.,Rioux, N.,Waters, N.J.,Tang, C.,Raimondi, A.,Munchhof, M.,Mills, J.E.,Ribich, S.,Porter Scott, M.,Kuntz, K.W.,Janzen, W.P.,Moyer, M.,Smith, J.J.,Chesworth, R.,Copeland, R.A.,Boriack-Sjodin, P.A. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. Plos One, 13:e0197372-e0197372, 2018 Cited by PubMed: 29856759DOI: 10.1371/journal.pone.0197372 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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