6FZW
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![BU of 6fzw by Molmil](/molmil-images/mine/6fzw) | |
7JYA
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![BU of 7jya by Molmil](/molmil-images/mine/7jya) | Crystal structure of E3 ligase in complex with peptide | 分子名称: | ASN-ARG-ARG-ARG-ARG-TRP-ARG-GLU-ARG-GLN-ARG, Protein fem-1 homolog C, UNKNOWN ATOM OR ION | 著者 | Yan, X, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Dong, C, Structural Genomics Consortium (SGC) | 登録日 | 2020-08-30 | 公開日 | 2020-10-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Molecular basis for ubiquitin ligase CRL2 FEM1C -mediated recognition of C-degron. Nat.Chem.Biol., 17, 2021
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3OKR
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![BU of 3okr by Molmil](/molmil-images/mine/3okr) | |
4WQC
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![BU of 4wqc by Molmil](/molmil-images/mine/4wqc) | Thiosulfate dehydrogenase (TsdA) from Allochromatium vinosum - K208N mutant | 分子名称: | 1,2-ETHANEDIOL, HEME C, SULFATE ION, ... | 著者 | Brito, J.A, Denkmann, K, Pereira, I.A.C, Dahl, C, Archer, M. | 登録日 | 2014-10-21 | 公開日 | 2015-02-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Thiosulfate Dehydrogenase (TsdA) from Allochromatium vinosum: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO THIOSULFATE OXIDATION. J.Biol.Chem., 290, 2015
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6THL
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![BU of 6thl by Molmil](/molmil-images/mine/6thl) | Crystal structure of the complex between RTT106 and BCD1 | 分子名称: | Box C/D snoRNA protein 1, Rtt106p | 著者 | Charron, C, Bragantini, B, Manival, X, Charpentier, B. | 登録日 | 2019-11-20 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity. Nat Commun, 12, 2021
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4Z0X
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![BU of 4z0x by Molmil](/molmil-images/mine/4z0x) | |
7MOA
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![BU of 7moa by Molmil](/molmil-images/mine/7moa) | Cryo-EM structure of the c-MET II/HGF I complex bound with HGF II in a rigid conformation | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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7MOB
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![BU of 7mob by Molmil](/molmil-images/mine/7mob) | Cryo-EM structure of 2:2 c-MET/NK1 complex | 分子名称: | Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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7MO7
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![BU of 7mo7 by Molmil](/molmil-images/mine/7mo7) | Cryo-EM structure of 2:2 c-MET/HGF holo-complex | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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7MO9
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![BU of 7mo9 by Molmil](/molmil-images/mine/7mo9) | Cryo-EM map of the c-MET II/HGF I/HGF II (K4 and SPH) sub-complex | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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6LBG
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![BU of 6lbg by Molmil](/molmil-images/mine/6lbg) | Structure of OR51B2 bound FEM1C | 分子名称: | Protein fem-1 homolog C,Peptide from Olfactory receptor 51B2, SULFATE ION | 著者 | Chen, X, Liao, S, Xu, C. | 登録日 | 2019-11-14 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LE6
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![BU of 6le6 by Molmil](/molmil-images/mine/6le6) | Structure of LNLPTQGRAR bound FEM1C | 分子名称: | Protein fem-1 homolog C,10-mer peptide, SULFATE ION | 著者 | Chen, X, Liao, S, Xu, C. | 登録日 | 2019-11-24 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LEN
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![BU of 6len by Molmil](/molmil-images/mine/6len) | Structure of NS11 bound FEM1C | 分子名称: | Protein fem-1 homolog C,NS11 peptide | 著者 | Chen, x, Liao, S, Xu, C. | 登録日 | 2019-11-25 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.383 Å) | 主引用文献 | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6AU4
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![BU of 6au4 by Molmil](/molmil-images/mine/6au4) | Crystal structure of the major quadruplex formed in the human c-MYC promoter | 分子名称: | DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION | 著者 | Stump, S, Mou, T.C, Sprang, S.R, Natale, N.R, Beall, H.D. | 登録日 | 2017-08-30 | 公開日 | 2018-09-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene. PLoS ONE, 13, 2018
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6LBN
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![BU of 6lbn by Molmil](/molmil-images/mine/6lbn) | Structure of SIL1-bound FEM1C | 分子名称: | Protein fem-1 homolog C,Peptide from Nucleotide exchange factor SIL1 | 著者 | Chen, X, Liao, S, Xu, C. | 登録日 | 2019-11-14 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.899 Å) | 主引用文献 | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LF0
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![BU of 6lf0 by Molmil](/molmil-images/mine/6lf0) | Structure of FEM1C | 分子名称: | Protein fem-1 homolog C, SULFATE ION | 著者 | Chen, X, Liao, S, Xu, C. | 登録日 | 2019-11-27 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LEY
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![BU of 6ley by Molmil](/molmil-images/mine/6ley) | Structure of Sil1G bound FEM1C | 分子名称: | Protein fem-1 homolog C,Peptide from Nucleotide exchange factor SIL1 | 著者 | Chen, X, Liao, S, Xu, C. | 登録日 | 2019-11-27 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6SPT
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![BU of 6spt by Molmil](/molmil-images/mine/6spt) | High resolution crystal structure of N-terminal domain of PEX14 from Trypanosoma brucei in complex with the fist compound with sub-micromolar trypanocidal activity | 分子名称: | 5-[(4-methoxynaphthalen-1-yl)methyl]-1-[2-[(2-methyl-1-oxidanyl-propan-2-yl)amino]ethyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | 著者 | Napolitano, V, Dawidowski, M, Kalel, V.C, Fino, R, Emmanouilidis, L, Lenhart, D, Ostertag, M, Kaiser, M, Kolonko, M, Schilebs, W, Maser, P, Tetko, I, Hadian, K, Plettenburg, O, Erdmann, R, Sattler, M, Popowicz, G.M, Dubin, G. | 登録日 | 2019-09-02 | 公開日 | 2020-01-01 | 最終更新日 | 2020-02-05 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity. J.Med.Chem., 63, 2020
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3O8I
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![BU of 3o8i by Molmil](/molmil-images/mine/3o8i) | Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment | 分子名称: | 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one | 著者 | Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P. | 登録日 | 2010-08-03 | 公開日 | 2010-09-29 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling Mol.Cell.Biol., 30, 2010
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4WTD
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![BU of 4wtd by Molmil](/molmil-images/mine/4wtd) | CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MANGANESE (II) ION, ... | 著者 | Edwards, T.E, Fox III, D, Appleby, T.C. | 登録日 | 2014-10-29 | 公開日 | 2015-02-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
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4WTJ
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![BU of 4wtj by Molmil](/molmil-images/mine/4wtj) | CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-AUCC, RNA PRIMER 5'-PGG, MN2+, AND ADP | 分子名称: | 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Edwards, T.E, Appleby, T.C. | 登録日 | 2014-10-30 | 公開日 | 2015-02-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
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4WTM
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![BU of 4wtm by Molmil](/molmil-images/mine/4wtm) | CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UAGG, RNA PRIMER 5'-PCC, MN2+, AND UDP | 分子名称: | CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER CC, ... | 著者 | Edwards, T.E, Appleby, T.C, Fox III, D. | 登録日 | 2014-10-30 | 公開日 | 2015-02-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
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3OP0
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![BU of 3op0 by Molmil](/molmil-images/mine/3op0) | Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide | 分子名称: | Epidermal growth factor receptor, NICKEL (II) ION, SODIUM ION, ... | 著者 | Chaikuad, A, Guo, K, Cooper, C.D.O, Ayinampudi, V, Krojer, T, Ugochukwu, E, Muniz, J.R.C, Vollmar, M, Canning, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) | 登録日 | 2010-08-31 | 公開日 | 2010-10-20 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide To be Published
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7JNT
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![BU of 7jnt by Molmil](/molmil-images/mine/7jnt) | |
3P8O
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![BU of 3p8o by Molmil](/molmil-images/mine/3p8o) | Crystal structure of HCV NS3/NS4A protease complexed with des-bromine analogue of BI 201335 | 分子名称: | HCV non-structural protein 4A, HCV serine protease NS3, N-[(cyclopentyloxy)carbonyl]-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-{2-[(2-methylpropanoyl)amino]-1,3-thiazol-4-yl}quinolin-4-yl)oxy]-L-prolinamide, ... | 著者 | Lemke, C.T. | 登録日 | 2010-10-14 | 公開日 | 2011-01-26 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335. J.Biol.Chem., 286, 2011
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