8PNK
 
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8PO8
 | | Structure of Escherichia coli HrpA in complex with ADP and oligonucleotide poly(dC)11 forming an i-motif | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase HrpA, DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), ... | | 著者 | Xin, B.G, Yuan, L.G, Zhang, L.L, Xie, S.M, Liu, N.N, Ai, X, Li, H.H, Rety, S, Xi, X.G. | | 登録日 | 2023-07-03 | | 公開日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
Nucleic Acids Res., 52, 2024
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8PO7
 | | Structure of Escherichia coli HrpA in complex with ADP and dinucleotide dCdC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase HrpA, DNA (5'-D(P*CP*C)-3'), ... | | 著者 | Xin, B.G, Yuan, L.G, Zhang, L.L, Xie, S.M, Liu, N.N, Ai, X, Li, H.H, Rety, S, Xi, X.G. | | 登録日 | 2023-07-03 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
Nucleic Acids Res., 52, 2024
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8PO6
 | | Structure of Escherichia coli HrpA apo form | | 分子名称: | ATP-dependent RNA helicase HrpA, PHOSPHATE ION | | 著者 | Xin, B.G, Yuan, L.G, Zhang, L.L, Xie, S.M, Liu, N.N, Ai, X, Li, H.H, Rety, S, Xi, X.G. | | 登録日 | 2023-07-03 | | 公開日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | | 主引用文献 | Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
Nucleic Acids Res., 52, 2024
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8Q7Q
 | | Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-16 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
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8Q7W
 | | Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-17 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
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8Q7V
 | | Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-17 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
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8Q7X
 | | Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-17 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
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8Q91
 | | Structure of the human 20S U5 snRNP core | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Schneider, S, Galej, W.P. | | 登録日 | 2023-08-19 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
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8Q9T
 | | CryoEM structure of a S. Cerevisiae Ski238 complex bound to RNA | | 分子名称: | Antiviral helicase SKI2, Antiviral protein SKI8, RNA (5'-R(P*UP*UP*UP*U)-3'), ... | | 著者 | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | | 登録日 | 2023-08-21 | | 公開日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
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8QCB
 | | CryoEM structure of a S. Cerevisiae Ski2387 complex in the open state | | 分子名称: | Antiviral helicase SKI2, Antiviral protein SKI8, Superkiller protein 3, ... | | 著者 | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | | 登録日 | 2023-08-25 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
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8QCA
 | | CryoEM structure of a S. Cerevisiae Ski2387 complex in the closed state bound to RNA | | 分子名称: | Antiviral helicase SKI2, Antiviral protein SKI8, RNA (5'-R(P*UP*UP*UP*U)-3'), ... | | 著者 | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | | 登録日 | 2023-08-25 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
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8QCF
 | | yeast cytoplasmic exosome-Ski2 complex degrading a RNA substrate | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Antiviral helicase SKI2, Exosome complex component CSL4, ... | | 著者 | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | | 登録日 | 2023-08-25 | | 公開日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
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8QO9
 | | Cryo-EM structure of a human spliceosomal B complex protomer | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | | 登録日 | 2023-09-28 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (5.29 Å) | | 主引用文献 | New insights into the functions of B complex proteins revealed by cryo-EM of dimerized
spliceosomes
To Be Published
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8QOZ
 | | Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss RNA oligo, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-09-29 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
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8QP8
 | | Cryo-EM Structure of Pre-B Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-09-30 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
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8QP9
 | | Cryo-EM Structure of Pre-B+AMPPNP Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-09-30 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
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8QPA
 | | Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-01 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
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8QPB
 | | Cryo-EM Structure of Pre-B+ATP Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-01 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
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8QPK
 | | Cryo-EM Structure of Pre-B+5'ss Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-02 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
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7GQT
 | | Crystal Structure of Werner helicase fragment 517-945 in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, MAGNESIUM ION, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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7GQU
 | | Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, GLYCEROL, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Tagliente, O, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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7GQS
 | | Crystal Structure of Werner helicase fragment 517-945 in complex with ADP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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8QXD
 | | Cryo-EM structure of the cross-exon pre-B complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-24 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
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8QZS
 | | Cryo-EM structure of the cross-exon B-like complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-29 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
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