1FYR
 
 | | DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX | | 分子名称: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE | | 著者 | Schiering, N, Casale, E, Caccia, P, Giordano, P, Battistini, C. | | 登録日 | 2000-10-03 | | 公開日 | 2000-12-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.
Biochemistry, 39, 2000
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1FU6
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1FU5
 | | NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE COMPLEXED TO A DOUBLY PHOSPHORYLATED PEPTIDE DERIVED FROM POLYOMAVIRUS MIDDLE T ANTIGEN | | 分子名称: | DOUBLY PHOSPHORYLATED MIDDLE T ANTIGEN, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT | | 著者 | Weber, T, Schaffhausen, B, Liu, Y, Guenther, U.L. | | 登録日 | 2000-09-14 | | 公開日 | 2001-02-21 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site.
Biochemistry, 39, 2000
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1FMK
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1FHS
 | | THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES | | 分子名称: | GROWTH FACTOR RECEPTOR BOUND PROTEIN-2 | | 著者 | Senior, M.M, Frederick, A.F, Black, S, Perkins, L.M, Wilson, O, Snow, M.E, Wang, Y.-S. | | 登録日 | 1997-06-12 | | 公開日 | 1998-06-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The three-dimensional solution structure of the Src homology domain-2 of the growth factor receptor-bound protein-2.
J.Biomol.NMR, 11, 1998
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1FBZ
 | | Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity | | 分子名称: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK, {4-[2-ACETYLAMINO-2-(3-CARBAMOYL-2-CYCLOHEXYLMETHOXY-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENYL}-PHOSPHONIC ACID | | 著者 | Shakespeare, W, Yang, M, Bohacek, R, Cerasoli, F, Stebbis, K, Sundaramoorthi, R, Vu, C, Pradeepan, S, Metcalf, C, Haraldson, C, Merry, T, Dalgarno, D, Narula, S, Hatada, M, Lu, X, Van Schravendijk, M.R, Adams, S, Violette, S, Smith, J, Guan, W, Bartlett, C, Herson, J, Iuliucci, J, Weigele, M, Sawyer, T. | | 登録日 | 2000-07-17 | | 公開日 | 2000-08-23 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.
Proc.Natl.Acad.Sci.Usa, 97, 2000
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1F2F
 | | SRC SH2 THREF1TRP MUTANT | | 分子名称: | PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | | 著者 | Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. | | 登録日 | 2000-05-24 | | 公開日 | 2000-07-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis for specificity switching of the Src SH2 domain.
Mol.Cell, 5, 2000
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1F1W
 | | SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN | | 分子名称: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, S(PTR)VNVQN PHOSPHOPEPTIDE | | 著者 | Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. | | 登録日 | 2000-05-20 | | 公開日 | 2000-07-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for specificity switching of the Src SH2 domain.
Mol.Cell, 5, 2000
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1D4W
 | | CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE | | 分子名称: | SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE, T CELL SIGNAL TRANSDUCTION MOLECULE SAP | | 著者 | Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J. | | 登録日 | 1999-10-06 | | 公開日 | 1999-10-14 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
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1D4T
 | | CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE | | 分子名称: | SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE, T CELL SIGNAL TRANSDUCTION MOLECULE SAP | | 著者 | Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J. | | 登録日 | 1999-10-06 | | 公開日 | 1999-10-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
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1D1Z
 | | CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP | | 分子名称: | SAP SH2 DOMAIN, SULFATE ION | | 著者 | Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J. | | 登録日 | 1999-09-22 | | 公開日 | 1999-10-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
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1CWE
 | | HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE | | 分子名称: | P56LCK TYROSINE KINASE, PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO | | 著者 | Mikol, V. | | 登録日 | 1995-09-06 | | 公開日 | 1996-12-07 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
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1CWD
 | | HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE | | 分子名称: | (PHOSPHONOMETHYL)PHENYLALANINE-CONTAINING PEPTIDE PRO-GLU-GLY-ASP-PM3-GLU-GLU-VAL-LEU, P56LCK TYROSINE KINASE | | 著者 | Mikol, V. | | 登録日 | 1995-09-06 | | 公開日 | 1996-12-07 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
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1CSZ
 | | SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR | | 分子名称: | ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE | | 著者 | Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C. | | 登録日 | 1995-10-03 | | 公開日 | 1996-11-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
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1CSY
 | | SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR | | 分子名称: | ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE | | 著者 | Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C. | | 登録日 | 1995-10-03 | | 公開日 | 1996-11-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
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1CJ1
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1BMB
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1BM2
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1BLK
 | | NMR ENSEMBLE OF BLK SH2 DOMAIN USING CHEMICAL SHIFT REFINEMENT, 20 STRUCTURES | | 分子名称: | P55 BLK PROTEIN TYROSINE KINASE | | 著者 | Metzler, W.J, Leiting, B, Pryor, K, Mueller, L, Farmer II, B.T. | | 登録日 | 1996-03-26 | | 公開日 | 1997-03-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Biochemistry, 35, 1996
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1BLJ
 | | NMR ENSEMBLE OF BLK SH2 DOMAIN, 20 STRUCTURES | | 分子名称: | P55 BLK PROTEIN TYROSINE KINASE | | 著者 | Metzler, W.J, Leiting, B, Pryor, K, Mueller, L, Farmer II, B.T. | | 登録日 | 1996-03-26 | | 公開日 | 1997-03-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Biochemistry, 35, 1996
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1BKM
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1BKL
 | | SELF-ASSOCIATED APO SRC SH2 DOMAIN | | 分子名称: | PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN | | 著者 | Holland, D.R, Rubin, J.R. | | 登録日 | 1997-05-02 | | 公開日 | 1997-07-23 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Novel Pp60Src Sh2 Domain Crystal Structures: A 2.0 Angstrom Co-Crystal Structure of a D-Amino Acid Substituted Phosphopeptide Complex and a 2.1 Angstrom Apo Structure Displaying Self-Association
To be Published
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1BHH
 | | FREE P56LCK SH2 DOMAIN | | 分子名称: | P56 LCK TYROSINE KINASE SH2 DOMAIN, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK | | 著者 | Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. | | 登録日 | 1998-06-08 | | 公開日 | 1998-10-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
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1BHF
 | | P56LCK SH2 DOMAIN INHIBITOR COMPLEX | | 分子名称: | INHIBITOR ACE-IPA-GLU-GLU-ILE, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK | | 著者 | Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. | | 登録日 | 1998-06-08 | | 公開日 | 1998-10-21 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
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1BG1
 | | TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX | | 分子名称: | DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), PROTEIN (TRANSCRIPTION FACTOR STAT3B) | | 著者 | Becker, S, Groner, B, Muller, C.W. | | 登録日 | 1998-06-03 | | 公開日 | 1999-01-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Three-dimensional structure of the Stat3beta homodimer bound to DNA.
Nature, 394, 1998
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