1BM2

GRB2-SH2 DOMAIN IN COMPLEX WITH CYCLO-[N-ALPHA-ACETYL-L-THI ALYSYL-O-PHOSPHOTYROSYL-VALYL-ASPARAGYL-VALYL-PROLYL] (PKF273-791)

Summary for 1BM2

Entry DOI	10.2210/pdb1bm2/pdb
Descriptor	PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF273-791) (3 entities in total)
Functional Keywords	sh2 domain, signal transduction, adaptor protein, ras pathway, cyclic peptide, hormone-growth factor complex, hormone/growth factor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	14420.26
Authors	Rondeau, J.M.,Zurini, M. (deposition date: 1998-07-27, release date: 1998-08-05, Last modification date: 2023-11-15)
Primary citation	Ettmayer, P.,France, D.,Gounarides, J.,Jarosinski, M.,Martin, M.S.,Rondeau, J.M.,Sabio, M.,Topiol, S.,Weidmann, B.,Zurini, M.,Bair, K.W. Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J.Med.Chem., 42:971-980, 1999 Cited by PubMed: 10090780 DOI: 10.1021/jm9811007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation