1CJ1

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

Summary for 1CJ1

DescriptorPROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2), [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER (3 entities in total)
Functional Keywordssignal transduction, sh2 domain, phosphotyrosine, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus  P62993
Total number of polymer chains12
Total molecular weight142155.8
Authors
Rahuel, J. (deposition date: 1999-04-21, release date: 1999-12-22, Last modification date: 2017-10-04)
Primary citation
Furet, P.,Garcia-Echeverria, C.,Gay, B.,Schoepfer, J.,Zeller, M.,Rahuel, J.
Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.
J.Med.Chem., 42:2358-2363, 1999
PubMed: 10395476 (PDB entries with the same primary citation)
DOI: 10.1021/jm991013u
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27325010.6%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-07-29