1CJ1

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE C78 A 155

Chain	Residue
A	HOH3
A	LYS109
A	LEU111
A	LEU120
A	TRP121
F	C78160
A	ARG67
A	ARG86
A	SER88
A	SER90
A	SER96
A	GLN106
A	HIS107
A	PHE108

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 B 156

Chain	Residue
B	ARG67
B	ARG86
B	SER88
B	SER90
B	SER96
B	GLN106
B	HIS107
B	PHE108
B	LYS109
B	LEU111
B	LEU120
B	TRP121
D	C78158

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 C 157

Chain	Residue
C	ARG67
C	ARG86
C	SER88
C	SER90
C	SER96
C	GLN106
C	HIS107
C	PHE108
C	LYS109
C	LEU111
C	LEU120
C	TRP121
E	C78159

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE C78 D 158

Chain	Residue
B	LEU111
B	C78156
D	ARG67
D	ARG86
D	SER88
D	SER90
D	SER96
D	GLN106
D	HIS107
D	PHE108
D	LYS109
D	LEU111
D	LEU120
D	TRP121

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 E 159

Chain	Residue
C	C78157
E	ARG67
E	ARG86
E	SER88
E	SER90
E	SER96
E	GLN106
E	HIS107
E	PHE108
E	LYS109
E	LEU111
E	LEU120
E	TRP121

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 F 160

Chain	Residue
A	C78155
F	ARG67
F	ARG86
F	SER88
F	SER90
F	SER96
F	GLN106
F	HIS107
F	PHE108
F	LYS109
F	LEU111
F	LEU120
F	TRP121

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 G 161

Chain	Residue
G	ARG67
G	ARG86
G	SER88
G	SER90
G	SER96
G	GLN106
G	HIS107
G	PHE108
G	LYS109
G	LEU111
G	LEU120
G	TRP121
K	C78165

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 H 162

Chain	Residue
H	HIS107
H	PHE108
H	LYS109
H	LEU111
H	LEU120
H	TRP121
J	C78164
H	ARG67
H	ARG86
H	SER88
H	SER90
H	SER96
H	GLN106

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 I 163

Chain	Residue
I	ARG67
I	ARG86
I	SER88
I	SER90
I	SER96
I	GLN106
I	HIS107
I	PHE108
I	LYS109
I	LEU111
I	LEU120
I	TRP121
L	C78166

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE C78 J 164

Chain	Residue
H	LEU111
H	C78162
J	ARG67
J	ARG86
J	SER88
J	SER90
J	SER96
J	GLN106
J	HIS107
J	PHE108
J	LYS109
J	LEU111
J	LEU120
J	TRP121

---

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 K 165

Chain	Residue
G	C78161
K	ARG67
K	ARG86
K	SER88
K	SER90
K	SER96
K	GLN106
K	HIS107
K	PHE108
K	LYS109
K	LEU111
K	LEU120
K	TRP121

---

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE C78 L 166

Chain	Residue
I	C78163
L	ARG67
L	ARG86
L	SER88
L	SER90
L	SER96
L	GLN106
L	HIS107
L	PHE108
L	LYS109
L	LEU111
L	LEU120
L	TRP121

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1104
Details	Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34348893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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