1CSY

SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR

Summary for 1CSY

DescriptorSYK PROTEIN TYROSINE KINASE, ACETYL-THR-PTR-GLU-THR-LEU-NH2 (2 entities in total)
Functional Keywordsprotein-tyrosine kinase sh2 domain, complex (phosphotransferase-peptide), complex (phosphotransferase-peptide) complex, complex (phosphotransferase/peptide)
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight13464.36
Authors
Narula, S.S.,Yuan, R.W.,Adams, S.E.,Green, O.M.,Green, J.,Phillips, T.B.,Zydowsky, L.D.,Botfield, M.C.,Hatada, M.H.,Laird, E.R.,Zoller, M.J.,Karas, J.L.,Dalgarno, D.C. (deposition date: 1995-10-03, release date: 1996-11-08, Last modification date: 2012-02-22)
Primary citation
Narula, S.S.,Yuan, R.W.,Adams, S.E.,Green, O.M.,Green, J.,Philips, T.B.,Zydowsky, L.D.,Botfield, M.C.,Hatada, M.,Laird, E.R.,Zoller, M.J.,Karas, J.L.,Dalgarno, D.C.
Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3:1061-1073, 1995
PubMed: 8590001 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(01)00242-8
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1039.5%28.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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