PDB: 1583 件ウェブページステータス検索Chemie searchBIRD

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4BTL	Aromatic interactions in acetylcholinesterase-inhibitor complexes 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, ... 著者 Andersson, C.D, Forsgren, N, Akfur, C, Allgardsson, A, Qian, W, Engdahl, C, Berg, L, Ekstrom, F, Linusson, A. 登録日 2013-06-18 公開日 2013-09-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors. J.Med.Chem., 56, 2013
7TMW	Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs 分子名称: Camelid antibody VHH fragment Nb35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Erlandson, S.C, Rawson, S, Kruse, A.C. 登録日 2022-01-20 公開日 2023-02-15 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. Nat.Chem.Biol., 19, 2023
8IRV	Dopamine Receptor D5R-Gs-Rotigotine complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. 登録日 2023-03-19 公開日 2023-06-07 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
8IRR	Dopamine Receptor D1R-Gs-Rotigotine complex 分子名称: CHOLESTEROL, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. 登録日 2023-03-19 公開日 2023-06-21 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
5HCU	Crystal structure of mouse acetylchoinesterase inhibited by DFP 分子名称: Acetylcholinesterase 著者 Tran, T.H, Tong, L. 登録日 2016-01-04 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4151 Å) 主引用文献 Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates. Chembiochem, 16, 2015
2HA0	Crystal structure of mouse acetylcholinesterase complexed with 4-ketoamyltrimethylammonium 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, Acetylcholinesterase, ... 著者 Bourne, Y, Radic, Z, Sulzenbacher, G, Kim, E, Taylor, P, Marchot, P. 登録日 2006-06-12 公開日 2006-07-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding J.Biol.Chem., 281, 2006
2HA3	Crystal structure of mouse acetylcholinesterase complexed with choline 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, CHOLINE ION, ... 著者 Bourne, Y, Radic, Z, Sulzenbacher, G, Kim, E, Taylor, P, Marchot, P. 登録日 2006-06-12 公開日 2006-07-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding J.Biol.Chem., 281, 2006
2HA5	Crystal structure of mutant S203A of acetylcholinesterase complexed with acetylthiocholine 分子名称: 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Bourne, Y, Radic, Z, Sulzenbacher, G, Kim, E, Taylor, P, Marchot, P. 登録日 2006-06-12 公開日 2006-07-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding J.Biol.Chem., 281, 2006
2HA2	Crystal structure of mouse acetylcholinesterase complexed with succinylcholine 分子名称: 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Bourne, Y, Radic, Z, Sulzenbacher, G, Kim, E, Taylor, P, Marchot, P. 登録日 2006-06-12 公開日 2006-07-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding J.Biol.Chem., 281, 2006
2HA6	Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with succinylcholine 分子名称: 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), ACETIC ACID, Acetylcholinesterase, ... 著者 Bourne, Y, Radic, Z, Sulzenbacher, G, Kim, E, Taylor, P, Marchot, P. 登録日 2006-06-12 公開日 2006-07-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding J.Biol.Chem., 281, 2006
2H9Y	Crystal structure of mouse acetylcholinesterase complexed with m-(N,N,N-trimethylammonio)trifluoroacetophenone 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, HEXAETHYLENE GLYCOL, ... 著者 Bourne, Y, Radic, Z, Sulzenbacher, G, Kim, E, Taylor, P, Marchot, P. 登録日 2006-06-12 公開日 2006-07-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding J.Biol.Chem., 281, 2006
2HA7	Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with butyrylthiocholine 分子名称: 2-(BUTYRYLSULFANYL)-N,N,N-TRIMETHYLETHANAMINIUM, 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, Acetylcholinesterase, ... 著者 Bourne, Y, Radic, Z, Sulzenbacher, G, Kim, E, Taylor, P, Marchot, P. 登録日 2006-06-12 公開日 2006-07-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding J.Biol.Chem., 281, 2006
8DZP	momSalB bound Kappa Opioid Receptor in complex with Gi1 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.71 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZQ	momSalB bound Kappa Opioid Receptor in complex with GoA 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (2.82 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZS	GR89,696 bound Kappa Opioid Receptor in complex with Gz 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(z) subunit alpha, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.65 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZR	GR89,696 bound Kappa Opioid Receptor in complex with gustducin 分子名称: G alpha gustducin protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
4QAA	X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 6-(4-Methoxyphenyl)-N4-octylpyrimidine-2,4-diamine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(4-methoxyphenyl)-N~4~-octylpyrimidine-2,4-diamine, Acetylcholine-binding protein, ... 著者 Kaczanowska, K, Harel, M, Radic, Z, Changeux, J.-P, Finn, M.G, Taylor, P. 登録日 2014-05-03 公開日 2014-07-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein. Proc.Natl.Acad.Sci.USA, 111, 2014
5FKJ	Crystal structure of mouse acetylcholinesterase in complex with C-547, an alkyl ammonium derivative of 6-methyl uracil 分子名称: 1,3-BIS[5(DIETHYL-O-NITROBENZYLAMMONIUM)PENTYL]-6-METHYLURACIL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... 著者 Nachon, F, Villard-Wandhammer, M, Petrov, K, Masson, P. 登録日 2015-10-16 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.133 Å) 主引用文献 Slow-Binding Inhibition of Acetylcholinesterase by a 6-Methyluracil Alkyl-Ammonium Derivative: Mechanism and Advantages for Myasthenia Gravis Treatment. Biochem.J., 473, 2016
4EY8	Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, Fasciculin-2, ... 著者 Cheung, J, Rudolph, M, Burshteyn, F, Cassidy, M, Gary, E, Love, J, Height, J, Franklin, M. 登録日 2012-05-01 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5958 Å) 主引用文献 Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem., 55, 2012
4QAC	X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(4-methylpiperidin-1-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine, Acetylcholine-binding protein, ... 著者 Kaczanowska, K, Harel, M, Radic, Z, Changeux, J.-P, Finn, M.G, Taylor, P. 登録日 2014-05-03 公開日 2014-07-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein. Proc.Natl.Acad.Sci.USA, 111, 2014
4QAB	X-RAY STRUCTURE of ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(MORPHOLIN-4-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(morpholin-4-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine, Acetylcholine-binding protein, ... 著者 Kaczanowska, K, Harel, M, Radic, Z, Changeux, J.-P, Finn, M.G, Taylor, P. 登録日 2014-05-03 公開日 2014-07-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.984 Å) 主引用文献 Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein. Proc.Natl.Acad.Sci.USA, 111, 2014
4EY4	Crystal Structure of Recombinant Human Acetylcholinesterase in the Apo state 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Cheung, J, Rudolph, M, Burshteyn, F, Cassidy, M, Gary, E, Love, J, Height, J, Franklin, M. 登録日 2012-05-01 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.156 Å) 主引用文献 Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem., 55, 2012
4EY7	Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Donepezil 分子名称: 1,2-ETHANEDIOL, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Cheung, J, Rudolph, M, Burshteyn, F, Cassidy, M, Gary, E, Love, J, Height, J, Franklin, M. 登録日 2012-05-01 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3509 Å) 主引用文献 Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem., 55, 2012
6WVQ	Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GP 分子名称: (1S)-2,2-dimethylcyclopentyl (R)-methylphosphinate, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 McGuire, J.R, Bester, S.M, Pegan, S.D, Height, J.J. 登録日 2020-05-06 公開日 2021-02-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.289 Å) 主引用文献 Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6. Chem.Res.Toxicol., 34, 2021
6WVC	Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GD 分子名称: (1S)-2,2-dimethylcyclopentyl (R)-methylphosphinate, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 McGuire, J.R, Bester, S.M, Pegan, S.D, Height, J.J. 登録日 2020-05-05 公開日 2021-02-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.599 Å) 主引用文献 Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6. Chem.Res.Toxicol., 34, 2021

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