2HA7

Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with butyrylthiocholine

Summary for 2HA7

Entry DOI	10.2210/pdb2ha7/pdb
Related	1J06 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6
Descriptor	Acetylcholinesterase, IODIDE ION, 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, ... (7 entities in total)
Functional Keywords	hydrolase fold, serine esterase, acetylcholinesterase, mutant, homodimer, glycosylated protein, hydrolase
Biological source	Mus musculus (house mouse)
Cellular location	Cell junction, synapse. Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side: P21836
Total number of polymer chains	2
Total formula weight	121718.78
Authors	Bourne, Y.,Radic, Z.,Sulzenbacher, G.,Kim, E.,Taylor, P.,Marchot, P. (deposition date: 2006-06-12, release date: 2006-07-18, Last modification date: 2023-10-25)
Primary citation	Bourne, Y.,Radic, Z.,Sulzenbacher, G.,Kim, E.,Taylor, P.,Marchot, P. Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding J.Biol.Chem., 281:29256-29267, 2006 Cited by PubMed: 16837465 DOI: 10.1074/jbc.M603018200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.66 Å)

Structure validation