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4EY7

Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Donepezil

Summary for 4EY7
Entry DOI10.2210/pdb4ey7/pdb
DescriptorAcetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, ... (7 entities in total)
Functional Keywordsacetylcholinesterase, hydrolase, donepezil, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight121325.70
Authors
Cheung, J.,Rudolph, M.,Burshteyn, F.,Cassidy, M.,Gary, E.,Love, J.,Height, J.,Franklin, M. (deposition date: 2012-05-01, release date: 2012-10-17, Last modification date: 2023-09-13)
Primary citationCheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J.
Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
J.Med.Chem., 55:10282-10286, 2012
Cited by
PubMed: 23035744
DOI: 10.1021/jm300871x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3509 Å)
Structure validation

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