5FKJ

Crystal structure of mouse acetylcholinesterase in complex with C-547, an alkyl ammonium derivative of 6-methyl uracil

Summary for 5FKJ

Entry DOI	10.2210/pdb5fkj/pdb
Descriptor	ACETYLCHOLINESTERASE, 1,3-BIS[5(DIETHYL-O-NITROBENZYLAMMONIUM)PENTYL]-6-METHYLURACIL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	hydrolase, acetylcholinesterase, c-547
Biological source	MUS MUSCULUS (HOUSE MOUSE)
Total number of polymer chains	4
Total formula weight	244389.58
Authors	Nachon, F.,Villard-Wandhammer, M.,Petrov, K.,Masson, P. (deposition date: 2015-10-16, release date: 2016-03-16, Last modification date: 2024-01-10)
Primary citation	Kharlamova, A.D.,Lushchekina, S.V.,Petrov, K.A.,Kots, E.D.,Nachon, F.V.,Villard-Wandhammer, M.,Zueva, I.V.,Krejci, E.,Reznik, V.S.,Zobov, V.V.,Nikolsky, E.E.,Masson, P. Slow-Binding Inhibition of Acetylcholinesterase by a 6-Methyluracil Alkyl-Ammonium Derivative: Mechanism and Advantages for Myasthenia Gravis Treatment. Biochem.J., 473:1225-, 2016 Cited by PubMed: 26929400 DOI: 10.1042/BCJ20160084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.133 Å)

Structure validation