PDB: 2718 件ウェブページステータス検索Chemie searchBIRD

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1L5R	Human liver glycogen phosphorylase a complexed with riboflavin, N-Acetyl-beta-D-Glucopyranosylamine and CP-403,700 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, N-acetyl-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... 著者 Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L. 登録日 2002-03-07 公開日 2002-12-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chem.Biol., 9, 2002
3LTQ	Structure of Interleukin 1B solved by SAD using an inserted Lanthanide Binding Tag 分子名称: ACETATE ION, Interleukin-1 beta, SULFATE ION, ... 著者 Peisach, E, Allen, K.N. 登録日 2010-02-16 公開日 2011-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Engineering encodable lanthanide-binding tags into loop regions of proteins. J.Am.Chem.Soc., 133, 2011
4DWB	Crystal structure of Trypanosoma cruzi farnesyl diphosphate synthase in complex with [2-(n-pentylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+ 分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ACETATE ION, Farnesyl pyrophosphate synthase, ... 著者 Aripirala, S, Amzel, L.M, Gabelli, S.B. 登録日 2012-02-24 公開日 2013-01-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. J.Med.Chem., 55, 2012
2Z78	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-806 分子名称: 3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2,2-diphosphonoethyl)pyridinium, Geranylgeranyl pyrophosphate synthetase 著者 Chen, C.K.-M, Guo, R.T, Hudock, M, Cao, R, Oldfield, E, Wang, A.H.-J. 登録日 2007-08-16 公開日 2008-07-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
5HHC	Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21/n 分子名称: D- Vascular endothelial growth factor-A, GLYCEROL, Vascular endothelial growth factor A 著者 Uppalapati, M, Lee, D.J, Mandal, K, Kent, S.B.H, Sidhu, S. 登録日 2016-01-10 公開日 2016-03-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. Acs Chem.Biol., 11, 2016
3BD8	Glucogen Phosphorylase complex with 1(-D-glucopyranosyl) cytosine 分子名称: 4-amino-1-beta-D-glucopyranosylpyrimidin-2(1H)-one, Glycogen phosphorylase, muscle form, ... 著者 Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. 登録日 2007-11-14 公開日 2008-11-18 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
2Z7I	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-742 分子名称: (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION 著者 Guo, R.T, Chen, C.K.-M, Ko, T.-P, Cao, R, Hudock, M, Oldfield, E, Wang, A.H.-J. 登録日 2007-08-23 公開日 2008-07-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
8UGH	In-situ structure of typeA supercomplex with lipids in respiratory chain (composite) 分子名称: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ... 著者 Zheng, W, Zhang, K, Zhu, J. 登録日 2023-10-05 公開日 2024-06-19 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 631, 2024
8ANA	Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the 50S ribosomal subunit 分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, 50S ribosomal protein L13, ... 著者 Koller, T.O, Morici, M, Wilson, D.N. 登録日 2022-08-05 公開日 2023-03-08 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Structural basis for translation inhibition by the glycosylated drosocin peptide. Nat.Chem.Biol., 19, 2023
5DIQ	Crystal structure of human FPPS in complex with salicylic acid derivative 3a 分子名称: 2-(naphthalen-1-ylmethoxy)benzoic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ... 著者 Rondeau, J.M, Bourgier, E, Lehmann, S. 登録日 2015-09-01 公開日 2015-09-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
5HHD	Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21 分子名称: D-Peptide RFX037.D, D-Vascular endothelial growth factor, DI(HYDROXYETHYL)ETHER, ... 著者 Uppalapati, M, LEE, D.J, Mandal, K, Kent, S.B.H, Sidhu, S. 登録日 2016-01-10 公開日 2016-03-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. Acs Chem.Biol., 11, 2016
8EMM	Composite 70S ribosome structure for "Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Watson, Z.L, Cate, J.H.D. 登録日 2022-09-28 公開日 2023-05-31 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates. Nat.Chem., 15, 2023
4Z5X	Glycogen phosphorylase in complex with gallic acid 分子名称: 3,4,5-trihydroxybenzoic acid, Glycogen phosphorylase, muscle form, ... 著者 Kyriakis, E, Kantsadi, L.A, Stravodimos, A.G, Chatzileontiadou, S.M.D, Leonidas, D.D. 登録日 2015-04-03 公開日 2015-05-13 最終更新日 2018-03-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b. Febs Lett., 589, 2015
6R37	T. brucei FPPS in complex with 2-(5-chlorobenzo[b]thiophen-3-yl)acetic acid 分子名称: (5-chloro-1-benzothiophen-3-yl)acetic acid, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase 著者 Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. 登録日 2019-03-19 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery Thesis, 2019
6W7I	LmFPPS mutant T164W in complex with 476A, IPP & Ca 分子名称: 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ... 著者 Maheshwari, S, Kim, Y.S, Aripirala, S, Gabelli, S.B. 登録日 2020-03-19 公開日 2020-10-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase. Biochemistry, 59, 2020
6YVE	Glycogen phosphorylase b in complex with pelargonidin 3-O-beta-D-glucoside 分子名称: DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ... 著者 Drakou, C.E, Gardeli, C, Tsialtas, I, Alexopoulos, S, Mallouchos, A, Koulas, S, Tsagkarakou, A, Asimakopoulos, D, Leonidas, D.D, Psarra, A.M, Skamnaki, V.T. 登録日 2020-04-28 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode. J.Agric.Food Chem., 68, 2020
7NZ1	Respiratory complex I from Escherichia coli - focused refinement of cytoplasmic arm 分子名称: CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... 著者 Kolata, P, Efremov, R.G. 登録日 2021-03-23 公開日 2021-08-18 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation. Elife, 10, 2021
1HOX	CRYSTAL STRUCTURE OF RABBIT PHOSPHOGLUCOSE ISOMERASE COMPLEXED WITH FRUCTOSE-6-PHOSPHATE 分子名称: 6-O-phosphono-beta-D-fructofuranose, PHOSPHOGLUCOSE ISOMERASE 著者 Jeffrey, C.J, Lee, J.H, Chang, K.Z, Patel, V. 登録日 2000-12-11 公開日 2001-07-20 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate. Biochemistry, 40, 2001
1TOO	Interleukin 1B Mutant F146W 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Guerrero, L, Caspar, D.L. 登録日 2004-06-14 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TWE	INTERLEUKIN 1 BETA MUTANT F101Y 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Capsar, D.L. 登録日 2004-06-30 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
5I1B	A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURINE INTERLEUKIN-1B 分子名称: INTERLEUKIN-1 BETA 著者 Ohlendorf, D.H, Salemme, F.R. 登録日 1990-09-07 公開日 1992-01-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A Comparison of the High Resolution Structures of Human and Murine Interleukin-1B To be Published
3DYG	T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, ACETATE ION, ... 著者 Cao, R, Gao, Y, Robinson, H, Goddard, A, Oldfield, E. 登録日 2008-07-27 公開日 2009-05-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc., 131, 2009
3MS2	Glycogen phosphorylase complexed with 4-methylbenzaldehyde-4-(beta-D-glucopyranosyl) thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-({(2E)-2-[(4-methylphenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-29 公開日 2011-01-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
2Z4Y	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252 分子名称: (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID), Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION 著者 Chen, C.K.-M, Guo, R.T, Hudock, M, Cao, R, Oldfield, E, Wang, A.H.-J. 登録日 2007-06-26 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
3MAV	Crystal structure of Plasmodium vivax putative farnesyl pyrophosphate synthase (Pv092040) 分子名称: Farnesyl pyrophosphate synthase, SULFATE ION 著者 Dong, A, Dunford, J, Lew, J, Wernimont, A.K, Ren, H, Zhao, Y, Koeieradzki, I, Opperman, U, Sundstrom, M, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) 登録日 2010-03-24 公開日 2010-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J.Biol.Chem., 286, 2011

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