2Z4Y

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252

Summary for 2Z4Y

Related2Z4V 2Z4W 2Z4X 2Z4Z 2Z50 2Z52
DescriptorGeranylgeranyl pyrophosphate synthetase, (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID), MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsprenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm (By similarity) Q12051
Total number of polymer chains2
Total molecular weight79535.07
Authors
Chen, C.K.-M.,Guo, R.T.,Hudock, M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-06-26, release date: 2008-07-01, Last modification date: 2011-07-13)
Primary citation
Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E.
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51:5594-5607, 2008
PubMed: 18800762 (PDB entries with the same primary citation)
DOI: 10.1021/jm800325y
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.232140.9%3.2%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution