2Z4X

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252 (P21)

Summary for 2Z4X

Entry DOI	10.2210/pdb2z4x/pdb
Related	2Z4V 2Z4W 2Z4Y 2Z4Z 2Z50 2Z52
Descriptor	Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID), ... (4 entities in total)
Functional Keywords	prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Cellular location	Cytoplasm (By similarity): Q12051
Total number of polymer chains	2
Total formula weight	79352.38
Authors	Guo, R.T.,Chen, C.K.-M.,Hudock, M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-06-26, release date: 2008-07-01, Last modification date: 2023-11-01)
Primary citation	Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51:5594-5607, 2008 Cited by PubMed: 18800762 DOI: 10.1021/jm800325y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation