2Z4X
S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252 (P21)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004311 | molecular_function | geranylgeranyl diphosphate synthase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0015031 | biological_process | protein transport |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0033384 | biological_process | geranyl diphosphate biosynthetic process |
| A | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004311 | molecular_function | geranylgeranyl diphosphate synthase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0015031 | biological_process | protein transport |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0033384 | biological_process | geranyl diphosphate biosynthetic process |
| B | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1201 |
| Chain | Residue |
| A | ASP80 |
| A | ASP84 |
| A | HOH1214 |
| A | HOH1224 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1202 |
| Chain | Residue |
| A | ASP80 |
| A | ASP84 |
| A | HOH1217 |
| A | HOH1512 |
| A | HOH1516 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1203 |
| Chain | Residue |
| A | HOH1308 |
| A | HOH1477 |
| A | HOH1481 |
| A | HOH1555 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1204 |
| Chain | Residue |
| B | ASP80 |
| B | ASP84 |
| B | HOH1208 |
| B | HOH1222 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1205 |
| Chain | Residue |
| B | ASP80 |
| B | ASP84 |
| B | HOH1239 |
| B | HOH1336 |
| B | HOH1338 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1206 |
| Chain | Residue |
| B | ASP214 |
| B | HOH1213 |
| B | HOH1253 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 252 A 1101 |
| Chain | Residue |
| A | SER76 |
| A | ASP80 |
| A | ASP84 |
| A | ARG89 |
| A | LEU143 |
| A | HIS144 |
| A | LYS174 |
| A | LYS238 |
| A | HOH1214 |
| A | HOH1224 |
| A | HOH1317 |
| A | HOH1365 |
| A | HOH1471 |
| A | HOH1477 |
| A | HOH1481 |
| A | HOH1512 |
| A | HOH1516 |
| A | HOH1555 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 252 B 1102 |
| Chain | Residue |
| B | ASP80 |
| B | ASP84 |
| B | ARG89 |
| B | LEU143 |
| B | HIS144 |
| B | GLN147 |
| B | LYS174 |
| B | ASP214 |
| B | LYS238 |
| B | HOH1208 |
| B | HOH1213 |
| B | HOH1222 |
| B | HOH1238 |
| B | HOH1239 |
| B | HOH1253 |
| B | HOH1336 |
| B | HOH1404 |
| B | HOH1435 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17535895","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16554305","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17535895","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for determining product chain length"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| A | TYR210 | |
| A | ARG89 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| B | TYR210 | |
| B | ARG89 |
