2Z4V

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)

Summary for 2Z4V

Entry DOI	10.2210/pdb2z4v/pdb
Related	2Z4W 2Z4X 2Z4Y 2Z4Z 2Z50 2Z52
Descriptor	Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, GERANYLGERANYL DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, transferase
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Cellular location	Cytoplasm (By similarity): Q12051
Total number of polymer chains	2
Total formula weight	79596.22
Authors	Chen, C.K.-M.,Guo, R.T.,Hudock, M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-06-26, release date: 2008-07-01, Last modification date: 2023-11-01)
Primary citation	Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51:5594-5607, 2008 Cited by PubMed: 18800762 DOI: 10.1021/jm800325y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation