2Z4Y

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004161	molecular_function	dimethylallyltranstransferase activity
A	0004311	molecular_function	farnesyltranstransferase activity
A	0004337	molecular_function	geranyltranstransferase activity
A	0004659	molecular_function	prenyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006744	biological_process	ubiquinone biosynthetic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0010236	biological_process	plastoquinone biosynthetic process
A	0015031	biological_process	protein transport
A	0016114	biological_process	terpenoid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0033384	biological_process	geranyl diphosphate biosynthetic process
A	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
A	0045337	biological_process	farnesyl diphosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	1990234	cellular_component	transferase complex
B	0004161	molecular_function	dimethylallyltranstransferase activity
B	0004311	molecular_function	farnesyltranstransferase activity
B	0004337	molecular_function	geranyltranstransferase activity
B	0004659	molecular_function	prenyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006744	biological_process	ubiquinone biosynthetic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0010236	biological_process	plastoquinone biosynthetic process
B	0015031	biological_process	protein transport
B	0016114	biological_process	terpenoid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0033384	biological_process	geranyl diphosphate biosynthetic process
B	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
B	0045337	biological_process	farnesyl diphosphate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	1990234	cellular_component	transferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 1301

Chain	Residue
B	ASP214
B	LYS238
B	HOH1356
B	HOH1411
B	HOH1438

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 252 A 1201

Chain	Residue
A	ASP214
A	LYS238
A	HOH1373
A	HOH1375
A	HOH1395
A	ASP80
A	ARG89
A	LYS174
A	GLN211

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 252 A 1202

Chain	Residue
A	GLY40
A	ARG44
A	LEU47
A	HIS73
A	LEU77
A	ARG89
A	ARG90
A	TYR210
A	HOH1373

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 252 B 1203

Chain	Residue
B	ASP80
B	ARG89
B	LEU143
B	HIS144
B	LYS174
B	GLN211
B	ASP214
B	LYS238
B	HOH1356
B	HOH1411
B	HOH1438
B	HOH1439
B	HOH1465

---

Functional Information from PROSITE/UniProt

site_id	PS00444
Number of Residues	13
Details	POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. LGiiYQIrDDYlN

Chain	Residue	Details
A	LEU206-ASN218

---

site_id	PS00723
Number of Residues	15
Details	POLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LLiDDie..DnaplRRG

Chain	Residue	Details
A	LEU77-GLY91

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:17535895

Chain	Residue	Details
A	LYS41
A	LYS238
B	LYS41
B	ARG44
B	HIS73
B	ARG89
B	ARG90
B	LYS174
B	THR175
B	GLN211
B	ASN218
A	ARG44
B	LYS238
A	HIS73
A	ARG89
A	ARG90
A	LYS174
A	THR175
A	GLN211
A	ASN218

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16554305, ECO:0000269|PubMed:17535895

Chain	Residue	Details
A	ASP80
A	ASP84
B	ASP80
B	ASP84

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:17535895

Chain	Residue	Details
A	LYS228
B	LYS228

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for determining product chain length

Chain	Residue	Details
A	TYR112
B	TYR112

---