PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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5UCU	STRUCTURAL AND MECHANISTIC INSIGHTS INTO HEMOGLOBIN-CATALYZED HYDROGEN SULFIDE OXIDATION AND THE FATE OF POLYSULFIDE PRODUCTS 分子名称: HYDROSULFURIC ACID, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Vitvitsky, V, Yadav, P.K, An, S, Seravalli, J, Cho, U.-S, Banerjee, R. 登録日 2016-12-22 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.797 Å) 主引用文献 Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products. J. Biol. Chem., 292, 2017
7KMR	Crystal structure analysis of human KRAS mutant 分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2020-11-03 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Regulation of GTPase function by autophosphorylation. Mol.Cell, 82, 2022
5YBU	Structure of the KANK1 ankyrin domain in complex with KIF21A peptide 分子名称: KN motif and ankyrin repeat domain-containing protein 1, Kinesin-like protein KIF21A 著者 Guo, Q, Liao, S, Min, J, Xu, C, Structural Genomics Consortium (SGC) 登録日 2017-09-05 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J. Biol. Chem., 293, 2018
7CFW	Crystal structure of the receiver domain of sensor histidine kinase PA1611 (PA1611REC) from Pseudomonas aeruginosa PAO1 with calcium ion coordinated in the active site cleft 分子名称: CALCIUM ION, Histidine kinase 著者 Chen, S.K, Guan, H.H, Wu, P.H, Lin, L.T, Wu, M.C, Chang, H.Y, Chen, N.C, Lin, C.C, Chuankhayan, P, Huang, Y.C, Lin, P.J, Chen, C.J. 登録日 2020-06-29 公開日 2020-11-04 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Structural insights into the histidine-containing phospho-transfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa Iucrj, 7, 2020
5YCE	Sperm whale myoglobin swMb 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION 著者 Isogai, Y, Imamura, H, Nakae, S, Sumi, T, Takahashi, K, Nakagawa, T, Tsuneshige, A, Shirai, T. 登録日 2017-09-07 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (0.77 Å) 主引用文献 Tracing whale myoglobin evolution by resurrecting ancient proteins. Sci Rep, 8, 2018
5UHU	Solution conformation of cytochrome P450 MycG with mycinamicin IV bound 分子名称: MYCINAMICIN IV, Mycinamicin IV hydroxylase/epoxidase, PROTOPORPHYRIN IX CONTAINING FE 著者 Pochapsky, T.C, Tietz, D.R. 登録日 2017-01-12 公開日 2017-08-23 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG. Biochemistry, 56, 2017
8EML	Crystal Structure of Gsx2 Homeodomain in Complex with DNA 分子名称: DNA (5'-D(P*GP*AP*GP*CP*TP*AP*AP*TP*TP*AP*AP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*TP*TP*AP*AP*TP*TP*AP*GP*CP*TP*C)-3'), GS homeobox 2, ... 著者 Webb, J.A, Kovall, R.A. 登録日 2022-09-28 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal Structure of Gsx2 Homeodomain in Complex with DNA To Be Published
4OMO	Crystal structure of the c-Src tyrosine kinase SH3 domain mutant Q128E 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src 著者 Camara-Artigas, A, Bacarizo, J. 登録日 2014-01-27 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.04 Å) 主引用文献 Electrostatic Effects in the Folding of the SH3 Domain of the c-Src Tyrosine Kinase: pH-Dependence in 3D-Domain Swapping and Amyloid Formation. Plos One, 9, 2014
8ENJ	Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK) 分子名称: Mitogen-activated protein kinase 10, N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide 著者 Park, H, Mersal, K.I. 登録日 2022-09-30 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells. Eur.J.Med.Chem., 261, 2023
8ERN	Cyclin-free CDK2 in complex with Cpd21 分子名称: Cyclin-dependent kinase 2, GLYCEROL, N,3-dimethyl-4-({7-[(2S)-2-methylpyrrolidine-1-carbonyl]quinazolin-2-yl}amino)benzene-1-sulfonamide 著者 Murray, J.M, Oh, A. 登録日 2022-10-12 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Cyclin-free CDK2 in complex with Cpd21 To Be Published
6CXY	Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody Fab mAb-1_19A11 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Cadherin-1, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2018-04-04 公開日 2019-04-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody Fab mAb-1_19A11 to be published
7T8F	G93A mutant of human SOD1 bound with Ebselen in P21 space group 分子名称: ACETATE ION, N-phenyl-2-selanylbenzamide, Superoxide dismutase [Cu-Zn], ... 著者 Amporndanai, K, Hasnain, S.S. 登録日 2021-12-16 公開日 2023-01-25 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement. Sci Rep, 14, 2024
6JO1	Structure of the CYP102A1 Haem Domain with N-(S)-Ibuprofenoyl-L-Phenylalanine 分子名称: (2S)-2-[[(2S)-2-[4-(2-methylpropyl)phenyl]propanoyl]amino]-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, DIMETHYL SULFOXIDE, ... 著者 Stanfield, J.K, Kasai, C, Sugimoto, H, Shiro, Y, Watanabe, Y, Shoji, O. 登録日 2019-03-19 公開日 2020-03-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain. Angew.Chem.Int.Ed.Engl., 59, 2020
5YKS	Crystal structure of sucrose nonfermenting-related kinase (SNRK) 分子名称: SNF-related serine/threonine-protein kinase 著者 Wang, Y.L, Wang, J, Wu, J.W. 登録日 2017-10-16 公開日 2017-11-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the kinase and UBA domains of SNRK reveals a distinct UBA binding mode in the AMPK family. Biochem. Biophys. Res. Commun., 495, 2018
7CBX	Crystal structure of MAP2K7 complexed with a covalent inhibitor 12 分子名称: 3-(1H-indazol-3-yl)-5-(prop-2-enoylamino)-N-prop-2-ynyl-benzamide, Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL 著者 Kinoshita, T, Murakawa, Y. 登録日 2020-06-15 公開日 2020-09-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.061 Å) 主引用文献 Structural basis for producing selective MAP2K7 inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
5UL6	The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions 分子名称: Adapter molecule crk, Proline-rich motif of nonstructural protein 1 of influenza a virus 著者 Shen, Q, Zeng, D, Zhao, B, Li, P, Cho, J.H. 登録日 2017-01-24 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The Molecular Mechanisms Underlying the Hijack of Host Proteins by the 1918 Spanish Influenza Virus. ACS Chem. Biol., 12, 2017
7T8E	G93A mutant of human SOD1 in P21 space group 分子名称: ACETATE ION, SULFATE ION, Superoxide dismutase [Cu-Zn], ... 著者 Amporndanai, K, Hasnain, S.S. 登録日 2021-12-16 公開日 2023-01-25 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement. Sci Rep, 14, 2024
8ERD	Cyclin-free CDK2 in complex with Cpd17 分子名称: (2-{[1-(methanesulfonyl)piperidin-4-yl]amino}quinazolin-7-yl)[(2S)-2-methylpyrrolidin-1-yl]methanone, Cyclin-dependent kinase 2 著者 Murray, J.M, Oh, A. 登録日 2022-10-11 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Cyclin-free CDK2 in complex with Cpd17 To Be Published
4OQS	Crystal structure of CYP105AS1 分子名称: CYP105AS1, PROTOPORPHYRIN IX CONTAINING FE 著者 Leys, D. 登録日 2014-02-10 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc.Natl.Acad.Sci.USA, 112, 2015
7T9C	Crystal structure of dehaloperoxidase B in complex with thymol 分子名称: 5-METHYL-2-(1-METHYLETHYL)PHENOL, Dehaloperoxidase B, GLYCEROL, ... 著者 de Serrano, V.S, Ghiladi, R.A, Malewschik, T, Yun, D. 登録日 2021-12-18 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 The Multifunctional Globin Dehaloperoxidase as a Biocatalyst in the Oxidation of Monoterpenes To Be Published
6CUK	Engineered Cytochrome c from Rhodothermus marinus, Rma TDE 分子名称: Cytochrome c, HEME C 著者 Lewis, R.D, Buller, A.R, Arnold, F.H. 登録日 2018-03-26 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Catalytic iron-carbene intermediate revealed in a cytochromeccarbene transferase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4OV2	Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus 分子名称: CALCIUM ION, Neuronal calcium sensor 1 著者 Pandaleneni, S, Burgoyne, R, Mayans, O, Lian, L.-Y. 登録日 2014-02-19 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus To be Published
4OS3	Three-dimensional structure of the C65A-W112F double mutant of Human lipocalin-type Prostaglandin D Synthase apo-form 分子名称: Prostaglandin-H2 D-isomerase 著者 Perduca, M, Bovi, M, Bertinelli, M, Bertini, E, Destefanis, L, Carrizo, M.E, Capaldi, S, Monaco, H.L. 登録日 2014-02-12 公開日 2014-08-06 最終更新日 2014-12-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase. Acta Crystallogr.,Sect.D, 70, 2014
4OW8	Crystal structure of kinase domain of PknA from Mtb 分子名称: GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PknA 著者 Ravala, S.K, Singh, S, Yadav, G.S, Karthikeyan, S, Chakraborti, P.K. 登録日 2014-01-31 公開日 2015-02-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis. Febs J., 282, 2015
6CVC	Mycobacterium marinum cytochrome P450 CYP124A1 in the substrate-free form 分子名称: Cytochrome P450 124A1, Cyp124A1, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Child, S.A, Bruning, J.B, Bell, S.G. 登録日 2018-03-27 公開日 2019-03-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A comparison of the steroid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis To Be Published

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