7T8F

G93A mutant of human SOD1 bound with Ebselen in P21 space group

Summary for 7T8F

• Entry DOI: 10.2210/pdb7t8f/pdb
• Descriptor: Superoxide dismutase [Cu-Zn], ZINC ION, ACETATE ION, ... (5 entities in total)
• Functional Keywords: sod1, als, drug discovery, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 32556.24

Authors

Amporndanai, K.,Hasnain, S.S. (deposition date: 2021-12-16, release date: 2023-01-25, Last modification date: 2024-06-05)

• Primary citation: Watanabe, S.,Amporndanai, K.,Awais, R.,Latham, C.,Awais, M.,O'Neill, P.M.,Yamanaka, K.,Hasnain, S.S.; Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement.; Sci Rep, 14:12118-12118, 2024; PubMed: 38802492; DOI: 10.1038/s41598-024-62903-5

Experimental method

X-RAY DIFFRACTION (1.4 Å)