7KMR

Crystal structure analysis of human KRAS mutant

Summary for 7KMR

Entry DOI	10.2210/pdb7kmr/pdb
Descriptor	Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywords	hydrolase, gtpase, oncogenic
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	24146.99
Authors	Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2020-11-03, release date: 2021-11-10, Last modification date: 2023-10-18)
Primary citation	Johnson, C.W.,Seo, H.S.,Terrell, E.M.,Yang, M.H.,KleinJan, F.,Gebregiworgis, T.,Gasmi-Seabrook, G.M.C.,Geffken, E.A.,Lakhani, J.,Song, K.,Bashyal, P.,Popow, O.,Paulo, J.A.,Liu, A.,Mattos, C.,Marshall, C.B.,Ikura, M.,Morrison, D.K.,Dhe-Paganon, S.,Haigis, K.M. Regulation of GTPase function by autophosphorylation. Mol.Cell, 82:950-968.e14, 2022 Cited by PubMed: 35202574 DOI: 10.1016/j.molcel.2022.02.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.51 Å)

Structure validation