7KMR

Crystal structure analysis of human KRAS mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Isoform 2B of GTPase KRas	polymer	210	23703.8	1	UniProt (P01116) Pfam (PF00071) In PDB	Homo sapiens (Human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	A	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
3		water	water		18.0	136	Chemie (HOH)

Sequence modifications

A: 1 - 185 (UniProt: P01116)

PDB	External Database	Details
Met -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
Gly -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Gly -13	-	expression tag
Ser -12	-	expression tag
Gly -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Glu 59	Ala 59	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	23703.8
Non-Polymers*	Number of molecules	1
	Total formula weight	443.2
All*	Total formula weight	24147.0

*Water molecules are not included.