8ENJ
Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK)
Summary for 8ENJ
Entry DOI | 10.2210/pdb8enj/pdb |
Descriptor | Mitogen-activated protein kinase 10, N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide (2 entities in total) |
Functional Keywords | cancer, jnk, leukemia, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 53170.96 |
Authors | |
Primary citation | Mersal, K.I.,Abdel-Maksoud, M.S.,Ali, E.M.H.,Ammar, U.M.,Zaraei, S.O.,Haque, M.M.,Das, T.,Hassan, N.F.,Kim, E.E.,Lee, J.S.,Park, H.,Lee, K.H.,El-Gamal, M.I.,Kim, H.K.,Ibrahim, T.M.,Oh, C.H. Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells. Eur.J.Med.Chem., 261:115779-115779, 2023 Cited by PubMed: 37776574DOI: 10.1016/j.ejmech.2023.115779 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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